Over the past decade, it has become clear that mammalian genomes encode thousands of
long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological …

In mammals, dosage compensation of sex chromosomal genes between females (XX) and
males (XY) is achieved through X-chromosome inactivation (XCI). The X-linked X-inactive …

Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely
unclear. Here, acute perturbations (∼ 1 h) to actomyosin stress or ECM elasticity cause …

The nucleus is linked mechanically to the extracellular matrix via multiple polymers that
transmit forces to the nuclear envelope and into the nuclear interior. Here, we review some …

The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that
entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure …

The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

Tissue microenvironments are characterized not only in terms of chemical composition but
also by collective properties such as stiffness, which influences the contractility of a cell, its …

Polyploids—organisms that have multiple sets of chromosomes—are common in certain
plant and animal taxa, and can be surprisingly stable. The evidence that has emerged from …

Repeated rounds of nuclear envelope (NE) rupture and repair have been observed in
laminopathy and cancer cells and result in intermittent loss of nucleus compartmentalization …

The nuclear envelope defines the barrier between the nucleus and cytoplasm and features
inner and outer membranes separated by a perinuclear space (PNS). The inner nuclear …