The neural basis of psychedelic action

AC Kwan, DE Olson, KH Preller, BL Roth - Nature Neuroscience, 2022 - nature.com
Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …

Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders

FX Vollenweider, KH Preller - Nature Reviews Neuroscience, 2020 - nature.com
Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

Models of psychedelic drug action: modulation of cortical-subcortical circuits

MK Doss, MB Madden, A Gaddis, MB Nebel… - Brain, 2022 - academic.oup.com
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …

Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function

MW Johnson, PS Hendricks, FS Barrett… - Pharmacology & …, 2019 - Elsevier
The purpose of this paper is to provide an integrative review and offer novel insights
regarding human research with classic psychedelics (classic hallucinogens), which are …

Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms

A Inserra, D De Gregorio, G Gobbi, M Nader - Pharmacological Reviews, 2021 - Elsevier
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

[HTML][HTML] Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

RL Carhart-Harris, L Roseman, M Bolstridge… - Scientific reports, 2017 - nature.com
Psilocybin with psychological support is showing promise as a treatment model in psychiatry
but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and …

A neurophenomenological approach to non-ordinary states of consciousness: hypnosis, meditation, and psychedelics

C Timmermann, PR Bauer, O Gosseries… - Trends in cognitive …, 2023 - cell.com
No contemporary unifying framework has been provided for the study of non-ordinary states
of consciousness (NSCs) despite increased interest in hypnosis, meditation, and …

Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor

KH Preller, JB Burt, JL Ji, CH Schleifer, BD Adkinson… - Elife, 2018 - elifesciences.org
Background: Lysergic acid diethylamide (LSD) has agonist activity at various serotonin (5-
HT) and dopamine receptors. Despite the therapeutic and scientific interest in LSD, specific …

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

NL Mason, KPC Kuypers, F Müller, J Reckweg… - …, 2020 - nature.com
There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin,
for disorders characterized by distortions of the self-experience, like depression …

Effective connectivity changes in LSD-induced altered states of consciousness in humans

KH Preller, A Razi, P Zeidman… - Proceedings of the …, 2019 - National Acad Sciences
Psychedelics exert unique effects on human consciousness. The thalamic filter model
suggests that core effects of psychedelics may result from gating deficits, based on a …