The DNA repair protein O6‐Methylguanine‐DNA methyltransferase (MGMT) is suggested to
be associated with resistance to alkylating agents such as Temozolomide which is being …

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the
context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples …

DNA methylation is the most studied epigenetic mark and CpG methylation is central to
many biological processes and human diseases. Since cancer has highlighted the …

For many years cancer research has focused on genetic defects, but during the last decade
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …

Polycomb Group (PcG) proteins are transcriptional repressors that epigenetically modify
chromatin and participate in the establishment and maintenance of cell fates. These proteins …

The DNA repair enzyme O 6-methylguanine-DNA methyltransferase (MGMT) antagonizes
the genotoxic effects of alkylating agents. MGMT promoter methylation is the key mechanism …

Caveolae are abundant surface pits formed by the assembly of cytoplasmic proteins on a
platform generated by caveolin integral membrane proteins and membrane lipids. This …

The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …

Epigenetic mechanisms such as DNA methylation and modifications to histone proteins
regulate high-order DNA structure and gene expression. Aberrant epigenetic mechanisms …