Introduction Moxidectin is a milbemycin endectocide recently approved for the treatment of
human onchocerciasis. Onchocerciasis, earmarked for elimination of transmission, is a …

The mutualistic association between Wolbachia endosymbionts and their filarial nematode
hosts has been exploited as a validated drug target delivering macrofilaricidal outcomes …

Mansonellosis is caused by three filarial parasite species from the genus Mansonella that
commonly produce chronic human microfilaraemias: M. ozzardi, M. perstans and M …

The main onchocerciasis elimination strategy is annual Community-Directed Treatment with
ivermectin (CDTi). However, as a response to persistent high infection prevalence in …

Background Our study in CDTI-naïve areas in Nord Kivu and Ituri (Democratic Republic of
the Congo, DRC), Lofa County (Liberia) and Nkwanta district (Ghana) showed that a single …

Introduction Onchocerciasis is targeted for elimination mainly with annual community-
directed treatment with ivermectin (CDTI). High infection levels have been reported in South …

We trialed strategies to reach semi-nomadic population with interventions targeting
onchocerciasis including a combination of community knowledge and Geographical …

Abstract Development of direct acting macrofilaricides for the treatment of human filariases is
hampered by limitations in screening throughput imposed by the parasite life cycle. In vitro …

Human Onchocerciasis, caused by infection by the filarial nematode Onchocerca volvulus, is
a neglected public health disease that affects millions of people in the endemic regions of …

Background Alternative strategies are recommended to accelerate onchocerciasis
elimination in problematic areas including areas where annual ivermectin (IVM) distributions …