Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

The extracellular matrix (ECM) is increasingly recognized as an important regulator in breast
cancer. ECM in breast cancer development features numerous changes in composition and …

The integrin family of cell adhesion receptors regulates a diverse array of cellular functions
crucial to the initiation, progression and metastasis of solid tumours. The importance of …

The delineation of key molecular pathways has enhanced our knowledge of the biology of
tumor microenvironment, tumor dissemination, and carcinogenesis. The complexities of cell …

Bone, a calcified tissue composed of 60% inorganic component (hydroxyapatite), 10% water
and 30% organic component (proteins), has three functions: providing mechanical support …

The generation of prosthetic implant wear after total joint arthroplasty is recognized as the
major initiating event in development of periprosthetic osteolysis and aseptic loosening, the …

Integrins are main cell adhesion receptors serving as linker attaching cells to extracellular
matrix (ECM) and bidirectional hubs transmitting biochemical and mechanical signals …

The skeleton is a common destination for many cancer metastases including breast and
prostate cancer. There are many characteristics of bone that make it an ideal environment …

Introduction Studies in xenograft models and experimental models of metastasis have
implicated several β3 integrin-expressing cell populations, including endothelium, platelets …