Advances in our understanding of the mechanisms by which tumor cells detect drug-induced
DNA damage leading to apoptotic death have aided in the design of novel, potentially more …

Tumor immunology fundamentals suggest immunological surveillance has the ability to
recognize malignant cells and kill them before a tumor develops. However, cancer cells …

The multidrug resistance protein MRP4, a member of the ATP-binding cassette superfamily,
confers resistance to purine-based antiretroviral agents. However, the antiviral agent …

OBJECTIVE: Overexpression of epidermal growth factor receptor (EGFR) in glioblastoma
multiforme (GBM) secondary to EGFR gene amplification is associated with a more …

Malignant gliomas are the most common primary brain tumors in adults and, with few
exceptions, have a dismal prognosis despite the therapeutic use of surgery, radiation …

The ability of herpes simplex virus type 1 thymidine kinase (HSV-tk)-expressing cells
incubated with ganciclovir (GCV) to induce cytotoxicity in neighboring HSV-tk-negative …

Human pancreatic adenocarcinomas lose the ability to express sst2, the somatostatin
receptor, which mediates the antiproliferative effect of somatostatin. Reintroducing sst2 into …

The ability of herpes simplex virus type 1 thymidine kinase (HSV-TK)-expressing cells
incubated with ganciclovir (GCV) to induce cytotoxicity in neighboring HSV-TK-negative …

Although early clinical gene therapy trials for recurrent central nervous system neoplasms
showed the proof-of-principle, they did not fulfill the high expectations suggested by the …

G207 is a multimutated, conditionally replicating herpes simplex virus type 1 (HSV-1) that
retains an intact viral thymidine kinase (HSV-tk) gene. The virus exhibits oncolytic activity in …