Systemic autoinflammatory diseases (SAIDs) are a heterogeneous group of disorders
caused by excess activation of the innate immune system in an antigen-independent …

There is a heterogeneous group of rare illnesses that fall into the vasculitis category and are
characterized mostly by blood vessel inflammation. Ischemia and disrupted blood flow will …

The nucleotide-binding domain (NBD), leucine-rich repeat (LRR), and pyrin domain (PYD)-
containing protein 3 (NLRP3) inflammasome is a critical mediator of the innate immune …

Proinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory
response, which is essential for the proper functioning of our immune system. When …

NOD-like receptor protein 3 (NLRP3) inflammasome is closely related to silica particle-
induced chronic lung inflammation but its role in epithelial remodeling, repair and …

Inflammation is a key driver in the pathogenesis of cystic fibrosis (CF). We assessed the
effectiveness of elexacaftor/tezacaftor/ivacaftor (ETI) therapy on downregulating systemic …

Background Cryopyrin-associated periodic syndrome (CAPS) is associated with NLRP3
pathogenic variants, mostly located in the NACHT (neuronal apoptosis inhibitor protein …

Alzheimer's disease (AD) is a progressively neurodegenerative disease without effective
treatment. Here, we reported that the levels of expression and enzymatic activity of …

Erroneous activation of inflammasomes can lead to autoinflammatory diseases, a group of
genetically diverse but symptomatically similar disorders, termed inflammasomopathies. In …

Monogenic autoinflammatory disorders are linked to germline and somatic pathogenic
variants in several proteins that nucleate inflammasome complex. Associated phenotypes …