Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive
complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Next-generation genomic sequencing has identified multiple novel molecular alterations in
cancer. Since the identification of DNA methylation and histone modification, it has become …

Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

Epigenetic drug discovery field has evidenced significant advancement in the recent times.
A plethora of small molecule inhibitors have progressed to clinical stage investigations and …

Recent genomic studies have resulted in an emerging understanding of the role of
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …

Indoles constitute extensively explored heterocyclic ring systems with wide range of
applications in pathophysiological conditions that is, cancer, microbial and viral infections …

Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb repressive
complex 2 (PRC2), has attracted broad research attention in the past few years because of …

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …

5-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage
pathway. The MTAP gene is frequently deleted in human cancers because of its …