The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …

The past decade of cancer research has been marked by a growing appreciation of the role
of immunity in cancer. Mutations in the tumour genome can cause tumours to express …

Adoptive transfer of high-affinity chimeric antigen receptor (CAR) T cells targeting
hematological cancers has yielded impressive clinical results. However, safety concerns …

T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and
higher-affinity non-self peptides presented on major histocompatibility complex (pMHC) …

The generation and maintenance of CD 8+ T cell memory is crucial to long‐term host
survival, yet the basic tenets of CD 8+ T cell immunity are still being established. Recent …

The interaction between the T‐cell receptor (TCR) and its peptide–major histocompatibility
complex (pepMHC) ligand plays a critical role in determining the activity and specificity of …

T cells expressing antigen-specific T-cell receptors (TCRs) can mediate effective tumor
regression, but they often also are accompanied by autoimmune responses. To determine …

T‐cell destiny during thymic selection depends on the affinity of the TCR for autologous
peptide ligands presented in the context of MHC molecules. This is a delicately balanced …

T cell receptor (TCR) binding to diverse peptide-major histocompatibility complex (pMHC)
ligands results in various degrees of T cell activation. Here we analyze which binding …

In the thymus, high-affinity, self-reactive thymocytes are eliminated from the pool of
developing T cells, generating central tolerance. Here, we investigate how developing T …