Epigenetics and cervical cancer: from pathogenesis to therapy

J Fang, H Zhang, S Jin - Tumor Biology, 2014 - Springer
Although human papillomavirus (HPV) infection has been found in most of the cervical
cancer cases, additional genetic and epigenetic changes are required for disease …

Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science

N Wentzensen, ME Sherman, M Schiffman… - Gynecologic …, 2009 - Elsevier
OBJECTIVE: We wanted to identify the most promising methylation marker candidates for
cervical cancer early detection. METHODS: A systematic literature review was performed in …

[HTML][HTML] (-)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in …

MA Khan, A Hussain, MK Sundaram… - Oncology …, 2015 - spandidos-publications.com
There has been increasing evidence that numerous bioactive dietary agents can hamper the
process of carcinogenesis by targeting epigenetic alterations including DNA methylation …

[HTML][HTML] Detection of host cell gene/HPV DNA methylation markers: a promising triage approach for cervical cancer

L Zhang, W Tan, H Yang, S Zhang, Y Dai - Frontiers in Oncology, 2022 - frontiersin.org
Cervical cancer is the most prevalent gynecologic malignancy, especially in women of low-
and middle-income countries (LMICs). With a better understanding of the etiology and …

[HTML][HTML] Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix

KP Saavedra, PM Brebi, JCS Roa - Clinical epigenetics, 2012 - Springer
Cervical cancer (CC) is one of the most malignant tumors and the second or third most
common type of cancer in women worldwide. The association between human …

Epigenetic alterations in cervical carcinogenesis

A Szalmás, J Kónya - Seminars in cancer biology, 2009 - Elsevier
During cervical carcinogenesis, the major etiologic factor, the persistent oncogenic HPV
infection itself is not sufficient to immortalize and transform the epithelial host cells. Together …

[HTML][HTML] Aberrant DNA methylation in cervical carcinogenesis

HJ Yang - Chinese journal of cancer, 2013 - ncbi.nlm.nih.gov
Persistent infection with high-risk types of human papillomavirus (HPV) is known to cause
cervical cancer; however, additional genetic and epigenetic alterations are required for …

[HTML][HTML] Sequential gene promoter methylation during HPV-induced cervical carcinogenesis

FE Henken, SM Wilting, RM Overmeer… - British journal of …, 2007 - nature.com
We aimed to link DNA methylation events occurring in cervical carcinomas to distinct stages
of HPV-induced transformation. Methylation specific-multiplex ligation-dependent probe …

Assessment of gene promoter hypermethylation for detection of cervical neoplasia

GBA Wisman, ER Nijhuis, MO Hoque… - … journal of cancer, 2006 - Wiley Online Library
Current cervical cancer screening is based on morphological assessment of Pap smears
and associated with significant false negative and false positive results. Previously, we have …

Association between dense CADM1 promoter methylation and reduced protein expression in high‐grade CIN and cervical SCC

RM Overmeer, FE Henken, PJF Snijders… - The Journal of …, 2008 - Wiley Online Library
We previously showed that silencing of TSLC1, recently renamed CADM1, is functionally
involved in high‐risk HPV‐mediated cervical carcinogenesis. CADM1 silencing often results …