Radiation oncology exploits the biological interaction of radiation within tissue to promote
tumor death while minimizing damage to surrounding normal tissue. The clinical delivery of …

Among various gene therapy methods for cancer, suicide gene therapy attracts a special
attention because it allows selective conversion of non-toxic compounds into cytotoxic drugs …

The RAD54 family DNA translocases have several biochemical activities. One activity,
demonstrated previously for the budding yeast translocases, is ATPase-dependent …

Cancer remains one of the leading causes of death worldwide. Conventional therapeutic
strategies usually offer limited specificity, resulting in severe side effects and toxicity to …

Regulation of homologous recombination (HR) is central for cancer prevention. However,
too little HR can increase cancer incidence, whereas too much HR can drive cancer …

Homologous recombination serves multiple roles in DNA repair that are essential for
maintaining genomic stability. We here describe RI-1, a small molecule that inhibits the …

Emerging evidence suggests that Sirtuin 6 (SIRT6) functions as a longevity assurance gene
by promoting genomic stability, regulating metabolic processes and attenuating …

Targeting deficient mechanisms of cellular DNA repair still represents the basis for the
treatment of the majority of solid tumors, and increased DNA repair capacity is a hallmark …

Protein toxins confer a defense against predation/grazing or a superior pathogenic
competence upon the producing organism. Such toxins have been perfected through …

The DNA damage response (DDR) is essential for maintaining genomic stability and cell
survival. However, when tumour cells with deficiencies in HR are faced with radio-and …