Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease
in industrialized countries. NAFLD progresses through the inflammatory phase of non …

Background & Aims Endothelial dysfunction plays an essential role in liver injury, yet the
phenotypic regulation of liver sinusoidal endothelial cells (LSECs) remains unknown …

The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells
(LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in …

The most frequent cause of portal hypertension is liver cirrhosis, and many of lethal
complications of cirrhosis such as ascites and gastroesophageal variceal hemorrhage are …

Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other …

Liver fibrosis is a common feature of sustained liver injury and represents a major public
health problem worldwide. Fibrosis is an active research field and discoveries in the last …

Portal hypertension is a severe and frequent complication of chronic liver disease. Its
consequences, bleeding from gastroesophageal varices and portal hypertensive …

Experimental findings in vitro and in vivo illustrate enhanced hypoxia and the formation of
reactive oxygen species (ROS) within the kidney following the administration of iodinated …

Rather than being a constitutive enzyme as was first suggested, endothelial nitric oxide
synthase (eNOS) is dynamically regulated at the transcriptional, posttranscriptional, and …