Laser interstitial thermal therapy: a first line treatment for seizures due to hypothalamic hamartoma?

VX Du, SV Gandhi, HL Rekate, AD Mehta - Epilepsia, 2017 - Wiley Online Library
Successful treatment of hypothalamic hamartoma (HH) can result in the resolution of its
sequelae including epilepsy and rage attacks. Risks and morbidity of open surgical …

The role of surgery in the management of Lennox–Gastaut syndrome: a systematic review and meta‐analysis of the clinical evidence

V Thirunavu, R Du, JY Wu, AT Berg, SK Lam - Epilepsia, 2021 - Wiley Online Library
Lennox–Gastaut syndrome (LGS) is a severe form of childhood onset epilepsy in which
patients require multiple medications and may be candidates for palliative surgical …

Conceptualizing Lennox–Gastaut syndrome as a secondary network epilepsy

JS Archer, AEL Warren, GD Jackson… - Frontiers in neurology, 2014 - frontiersin.org
Lennox–Gastaut Syndrome (LGS) is a category of severe, disabling epilepsy, characterized
by frequent, treatment-resistant seizures, and cognitive impairment. Electroencephalography …

The missed value of underutilizing pediatric epilepsy surgery: a systematic review

CW Beatty, JP Lockrow, S Gedela, A Gehred… - Seminars in pediatric …, 2021 - Elsevier
Pediatric epilepsy surgery is underutilized. Only 1%-11% of children with drug resistant
epilepsy (DRE) undergo surgical treatment, or less than half of those estimated to benefit …

Lennox–Gastaut syndrome: a state of the art review

M Mastrangelo - Neuropediatrics, 2017 - thieme-connect.com
Lennox–Gastaut syndrome (LGS) is a severe age-dependent epileptic encephalopathy
usually with onset between 1 and 8 years of age. Functional neuroimaging studies recently …

Cognitive outcome after epilepsy surgery in children

ANV Moosa, E Wyllie - Seminars in pediatric neurology, 2017 - Elsevier
Cognitive dysfunction in children with epilepsy is primarily contributed by etiology, seizures,
frequency of interictal epileptiform discharges, and adverse effects of antiepileptic drugs …

Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions

AP Ostendorf, YT Ng - Neuropsychiatric Disease and Treatment, 2017 - Taylor & Francis
Lennox-Gastaut syndrome is a severe, childhood-onset electroclinical syndrome comprised
of multiple seizure types, intellectual and behavioral disturbances and characteristic findings …

[HTML][HTML] Seizure outcome and prognostic factors for surgical management of hypothalamic hamartomas in children

S Ferrand-Sorbets, M Fohlen, O Delalande, K Zuber… - Seizure, 2020 - Elsevier
Purpose Hypothalamic hamartomas (HH) are rare benign lesions frequently associated with
gelastic seizures early in life. Epilepsy can progress to multiple seizure types with cognitive …

Clinical trials for Lennox–Gastaut syndrome: Challenges and priorities

JK Knowles, AEL Warren, IS Mohamed… - Annals of Clinical …, 2024 - Wiley Online Library
Abstract Objective: Lennox‐Gastaut syndrome (LGS) is a severe, childhood‐onset epilepsy
that is typically refractory to treatment. We surveyed the current landscape of LGS treatment …

Epilepsy surgery in developmental and epileptic encephalopathies

G Ramantani, E Wirrell - Epilepsy & Behavior, 2024 - Elsevier
Developmental and epileptic encephalopathies (DEEs) present significant treatment
challenges due to frequent, drug-resistant seizures and comorbidities that impact quality of …