Tityus serrulatus venom–a lethal cocktail

MB Pucca, FA Cerni, ELP Junior, KCF Bordon… - Toxicon, 2015 - Elsevier
Tityus serrulatus (Ts) is the main scorpion species of medical importance in Brazil. Ts venom
is composed of several compounds such as mucus, inorganic salts, lipids, amines …

[HTML][HTML] Effects of Brazilian scorpion venoms on the central nervous system

ALA Nencioni, E Beraldo Neto, LA Freitas… - Journal of venomous …, 2018 - SciELO Brasil
In Brazil, the scorpion species responsible for most severe incidents belong to the Tityus
genus and, among this group, T. serrulatus, T. bahiensis, T. stigmurus and T. obscurus are …

Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities

J Boldrini-França, EL Pinheiro-Junior, S Peigneur… - Scientific Reports, 2020 - nature.com
Snake venom serine proteases (SVSPs) are complex and multifunctional enzymes, acting
primarily on hemostasis. In this work, we report the hitherto unknown inhibitory effect of a …

Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease

J Ciolek, H Reinfrank, L Quinton… - Proceedings of the …, 2017 - National Acad Sciences
Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and
death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the …

Scorpion toxin peptide action at the ion channel subunit level

DM Housley, GD Housley, MJ Liddell, EA Jennings - Neuropharmacology, 2017 - Elsevier
This review categorizes functionally validated actions of defined scorpion toxin (SCTX)
neuropeptides across ion channel subclasses, highlighting key trends in this rapidly …

Influence of post-starvation extraction time and prey-specific diet in Tityus serrulatus scorpion venom composition and hyaluronidase activity

MB Pucca, FG Amorim, FA Cerni, KCF Bordon… - Toxicon, 2014 - Elsevier
The role of diet in venom composition has been a topic of intense research interest. This
work presents evidence that the variation in the venom composition from the scorpion Tityus …

A venomics approach coupled to high-throughput toxin production strategies identifies the first venom-derived melanocortin receptor agonists

S Reynaud, J Ciolek, M Degueldre… - Journal of medicinal …, 2020 - ACS Publications
Animal venoms are rich in hundreds of toxins with extraordinary biological activities. Their
exploitation is difficult due to their complexity and the small quantities of venom available …

A gamut of undiscovered electrophysiological effects produced by Tityus serrulatus toxin 1 on NaV-type isoforms

S Peigneur, CT Cologna, CM Cremonez, BG Mille… - …, 2015 - Elsevier
In the last decades, Ts1 has not only been the subject of many studies, it has also been
considered as a very useful tool to investigate Na V channels and to explore the exact role of …

Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins

FG Amorim, HT Longhim, CT Cologna… - Journal of Venomous …, 2019 - SciELO Brasil
Abstract Background: Tityus serrulatus venom (Ts venom) is a complex mixture of several
compounds with biotechnological and therapeutical potentials, which highlights the …

[HTML][HTML] Novel components of Tityus serrulatus venom: A transcriptomic approach

Y Kalapothakis, K Miranda, AH Pereira, ASA Witt… - Toxicon, 2021 - Elsevier
Several research groups have studied the components produced by the venom gland of the
scorpion Tityus serrulatus, which has one of the most lethal venoms in the world. Various …