The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

The Wnt/β-catenin signaling pathway has been implicated as the central mechanism that
drives colorectal carcinogenesis. Its activation is historically due to mutation on APC …

The Wnt/β-catenin signaling is usually abnormally activated in hepatocellular carcinoma
(HCC), and pituitary tumor-transforming gene 1 (PTTG1) has been found to be highly …

Ubiquitylation is catalyzed by coordinated actions of E3 and E2 enzymes. Molecular
principles governing many important E3-E2 partnerships remain unknown, including those …

The ability to harness innate immunity is a promising solution for improving cancer
immunotherapy. Interferon (IFN) induces expression of IFN-stimulated genes (ISGs) by …

Abstract palmitoylation, a reversible post-translational modification, is initiated by the DHHC
family of palmitoyltransferases and reversed by several acyl protein thioesterases. However …

Liver metastasis is a major cause of death in gastric cancer patients, but the underlying
mechanisms are poorly understood. Through a combination of in vivo screening and …

Primary cilia extending from mother centrioles are essential for vertebrate development and
homeostasis maintenance. Centriolar coiled-coil protein 110 (CP110) has been reported to …

AXIN1, has been initially identified as a prominent antagonist within the WNT/β-catenin
signaling pathway, and subsequently unveiled its integral involvement across a diverse …

Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate
many cellular processes and embryonic development. m1A RNA modification plays key …