Genome-scale models in human metabologenomics

A Mardinoglu, BØ Palsson - Nature Reviews Genetics, 2024 - nature.com
Metabologenomics integrates metabolomics with other omics data types to comprehensively
study the genetic and environmental factors that influence metabolism. These multi-omics …

Integration of proteomic data with genome‐scale metabolic models: A methodological overview

F Zare, RMT Fleming - Protein Science, 2024 - Wiley Online Library
The integration of proteomics data with constraint‐based reconstruction and analysis
(COBRA) models plays a pivotal role in understanding the relationship between genotype …

Identification of metabolites reproducibly associated with Parkinson's Disease via meta-analysis and computational modelling

X Luo, Y Liu, A Balck, C Klein, RMT Fleming - npj Parkinson's Disease, 2024 - nature.com
Many studies have reported metabolomic analysis of different bio-specimens from
Parkinson's disease (PD) patients. However, inconsistencies in reported metabolite …

Omics data integration suggests a potential idiopathic Parkinson's disease signature

A Zagare, G Preciat, SL Nickels, X Luo… - Communications …, 2023 - nature.com
The vast majority of Parkinson's disease cases are idiopathic. Unclear etiology and
multifactorial nature complicate the comprehension of disease pathogenesis. Identification …

XomicsToModel: Multiomics data integration and generation of thermodynamically consistent metabolic models

G Preciat, AB Wegrzyn, I Thiele, T Hankemeier… - bioRxiv, 2021 - biorxiv.org
Constraint-based modelling can mechanistically simulate the behaviour of a biochemical
system, permitting hypotheses generation, experimental design and interpretation of …

Conserved moiety fluxomics

RMT Fleming, HS Haraldsdottir, G Preciat, L Huang… - bioRxiv, 2024 - biorxiv.org
Fluxomics seeks to infer reaction fluxes at genome-scale by introducing isotopically labelled
metabolites into a living system and measuring the enrichment of isotopic tracers in …