Fragile X is the most common known inherited cause of intellectual disability and autism,
and it typically results from transcriptional silencing of FMR1 and loss of the encoded …

The mental retardation protein FMRP is involved in the transport of mRNAs and their
translation at synapses. Patients with fragile X syndrome, in whom FMRP is absent or …

Strong evidence indicates that regulated mRNA translation in neuronal dendrites underlies
synaptic plasticity and brain development. The fragile X mental retardation protein (FMRP) is …

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …

Fragile X syndrome (FXS) results from the loss of the fragile X mental retardation protein
(FMRP), an RNA-binding protein that regulates a variety of cytoplasmic mRNAs. FMRP …

After our initial discovery of under expression of the GABAA receptor δ subunit in a genome
wide screening for differentially expressed mRNAs in brain of fragile X mice, a validated …

RNA is structurally very flexible, which provides the basis for its functional diversity. An RNA
molecule can often adopt different conformations, which enables the regulation of its …

Fragile-X mental retardation is caused by loss of function of a single gene encoding the
Fragile-X mental retardation protein, FMRP, an RNA-binding protein that harbors two KH …

Fragile X syndrome is caused by the absence of the fragile X mental retardation protein
(FMRP). This RNA-binding protein is widely expressed in human and mouse tissues, and it …

Fragile X syndrome, a common cause of intellectual disability and autism, is due to
mutational silencing of the FMR1 gene leading to the absence of its gene product, fragile X …