Scrub Typhus Pathogenesis: Innate Immune Response and Lung Injury During Orientia tsutsugamushi Infection
Scrub typhus is an understudied, potentially lethal disease caused by infection with Orientia
tsutsugamushi. Despite causing an estimated 1 million cases per year and an increasing …
tsutsugamushi. Despite causing an estimated 1 million cases per year and an increasing …
[HTML][HTML] Orientia tsutsugamushi: The dangerous yet neglected foe from the East
A Banerjee, S Kulkarni - International Journal of Medical Microbiology, 2021 - Elsevier
Orientia tsutsugamushi (OT), the causative agent of the vector-borne Scrub typhus zoonotic
disease in humans, is a unique microorganism that exists in the Asia-Pacific region since a …
disease in humans, is a unique microorganism that exists in the Asia-Pacific region since a …
Aberrant gut microbiome contributes to intestinal oxidative stress, barrier dysfunction, inflammation and systemic autoimmune responses in MRL/lpr mice
Microbiome composition and function have been implicated as contributing factors in the
pathogenesis of autoimmune diseases (ADs), including systemic lupus erythematosus …
pathogenesis of autoimmune diseases (ADs), including systemic lupus erythematosus …
Cell-type apoptosis in lung during SARS-CoV-2 infection
Y Liu, TM Garron, Q Chang, Z Su, C Zhou, Y Qiu… - Pathogens, 2021 - mdpi.com
The SARS-CoV-2 pandemic has inspired renewed interest in understanding the
fundamental pathology of acute respiratory distress syndrome (ARDS) following infection …
fundamental pathology of acute respiratory distress syndrome (ARDS) following infection …
A time-course comparative clinical and immune response evaluation study between the human pathogenic Orientia tsutsugamushi strains: Karp and Gilliam in a rhesus …
M Inthawong, P Sunyakumthorn… - PLoS Neglected …, 2022 - journals.plos.org
Background Scrub typhus is a vector-borne febrile illness caused by Orientia tsutsugamushi
transmitted by the bite of Trombiculid mites. O. tsutsugamushi has a high genetic diversity …
transmitted by the bite of Trombiculid mites. O. tsutsugamushi has a high genetic diversity …
Orientia tsutsugamushi selectively stimulates the C-type lectin receptor Mincle and type 1-skewed proinflammatory immune responses
Orientia tsutsugamushi is an obligately intracellular bacterium and the etiological agent of
scrub typhus. The lung is a major target organ of infection, displaying type 1-skewed …
scrub typhus. The lung is a major target organ of infection, displaying type 1-skewed …
Neuroinflammation associated with scrub typhus and spotted fever group rickettsioses
Scrub typhus and spotted fever rickettsioses (SFR) are understudied, vector-borne diseases
of global significance. Over 1 billion individuals are at risk for scrub typhus alone in an …
of global significance. Over 1 billion individuals are at risk for scrub typhus alone in an …
Orientia tsutsugamushi uses two Ank effectors to modulate NF-κB p65 nuclear transport and inhibit NF-κB transcriptional activation
SM Evans, KG Rodino, HE Adcox, JA Carlyon - PLoS pathogens, 2018 - journals.plos.org
Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that threatens over
one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central …
one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central …
Brain transcriptomics reveal the activation of neuroinflammation pathways during acute Orientia tsutsugamushi infection in mice
Scrub typhus, an acute febrile illness caused by Orientia tsutsugamushi (Ot), is prevalent in
endemic areas with one million new cases annually. Clinical observations suggest central …
endemic areas with one million new cases annually. Clinical observations suggest central …
Human umbilical cord-derived mesenchymal stromal cells improve myocardial fibrosis and restore miRNA-133a expression in diabetic cardiomyopathy
B Liu, Y Wei, J He, B Feng, Y Chen, R Guo… - Stem Cell Research & …, 2024 - Springer
Background Diabetic cardiomyopathy (DCM) is a serious health-threatening complication of
diabetes mellitus characterized by myocardial fibrosis and abnormal cardiac function …
diabetes mellitus characterized by myocardial fibrosis and abnormal cardiac function …