Background Men and women with chronic pain report increased alcohol use and are more
likely to be diagnosed with alcohol use disorder. The relationship between alcohol use and …

This study was designed to investigate the analgesic effect of perineural injection of BoNT/A
on neuropathic pain induced by sciatic nerve chronic constriction injury (CCI) and possible …

Background Standard methods assessing pain in rodents are often observer dependent,
potentially resulting in biased outcomes. Advanced dynamic weight bearing (ADWB) offers …

Background Moderate-to-severe acute pain is prevalent in many healthcare settings and
associated with adverse outcomes. Peripheral nerve blockade using traditional needle …

Thermosensation, the ability to detect and estimate temperature, is an evolutionarily
conserved process that is essential for survival. Thermosensing is impaired in various pain …

Abnormal encoding of somatosensory modalities (ie, mechanical, cold, and heat) are a
critical part of pathological pain states. Detailed phenotyping of patients' responses to these …

Pharmacological assays based on the measurement of nociceptive responses in laboratory
animals are a fundamental tool to assess analgesic strategies. During our experience with …

Neuropathic pain is a growing issue among the population and most current treatments
have been found to be ineffective. New targets such as Na v 1.8 have been identified as …

Pain is a sensation caused by potentially injurious stimuli that acts as a warning mechanism
necessary for survival. Pain that lasts beyond an injury, or is of unknown origin, can persist …

Neuropathic pain resulting from peripheral nerve injury is among the most debilitating types
of chronic pain conditions. Opioid medications are often used despite their poor efficacy in …