The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …

Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

At present, the prevalence of Alzheimer's disease, a devastating neurodegenerative
disorder, is increasing. Although the mechanism of the underlying pathology is not fully …

During starvation, mammalian brains can adapt their metabolism, switching from glucose to
alternative peripheral fuel sources. In the Drosophila starved brain, memory formation is …

3-hydroxybutyrate (3-HB) as a very important metabolite occurs in animals, bacteria and
plants. It is well known that in animals, 3-HB is formed as a product of the normal metabolism …

How do neurons match generation of adenosine triphosphate by mitochondria to the
bioenergetic demands of regenerative activity? Although the subject of speculation, this …

In the brain, mitochondrial metabolism has been largely associated with energy production,
and its dysfunction is linked to neuronal cell loss. However, the functional role of …

Patients with alcohol use disorder (AUD) present with important emotional, cognitive, and
social impairments. The gut microbiota has been recently shown to regulate brain functions …

The ketogenic diet, originally developed for the treatment of epilepsy in non-responder
children, is spreading to be used in the treatment of many diseases, including Alzheimer's …