Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

DA Butterfield, B Halliwell - Nature Reviews Neuroscience, 2019 - nature.com
Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …

Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease

DP Veitch, MW Weiner, PS Aisen… - Alzheimer's & …, 2022 - Wiley Online Library
Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has
accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic …

Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer's Disease and …

I Cumplido-Mayoral, M García-Prat, G Operto, C Falcon… - Elife, 2023 - elifesciences.org
Brain-age can be inferred from structural neuroimaging and compared to chronological age
(brain-age delta) as a marker of biological brain aging. Accelerated aging has been found in …

Prediction of amyloid pathology in cognitively unimpaired individuals using voxel-wise analysis of longitudinal structural brain MRI

PM Petrone, A Casamitjana, C Falcon… - Alzheimer's Research & …, 2019 - Springer
Background Magnetic resonance imaging (MRI) has unveiled specific alterations at different
stages of Alzheimer's disease (AD) pathophysiologic continuum constituting what has been …

An extensible hierarchical graph convolutional network for early Alzheimer's disease identification

X Tian, Y Liu, L Wang, X Zeng, Y Huang… - Computer Methods and …, 2023 - Elsevier
Abstract Background and Objective: For early identification of Alzheimer's disease (AD)
based on multi-modal magnetic resonance imaging (MRI) data, it is important to make …

[HTML][HTML] Real-world prediction of preclinical Alzheimer's disease with a deep generative model

U Hwang, SW Kim, D Jung, SW Kim, H Lee… - Artificial Intelligence in …, 2023 - Elsevier
Amyloid positivity is an early indicator of Alzheimer's disease and is necessary to determine
the disease. In this study, a deep generative model is utilized to predict the amyloid positivity …

The search for a convenient procedure to detect one of the earliest signs of Alzheimer's disease: a systematic review of the prediction of brain amyloid status

MT Ashford, DP Veitch, J Neuhaus… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Convenient, cost‐effective tests for amyloid beta (Aβ) are needed to identify
those at higher risk for developing Alzheimer's disease (AD). This systematic review …

Amyloid-β prediction machine learning model using source-based morphometry across neurocognitive disorders

Y Momota, S Bun, J Hirano, K Kamiya, R Ueda… - Scientific reports, 2024 - nature.com
Previous studies have developed and explored magnetic resonance imaging (MRI)-based
machine learning models for predicting Alzheimer's disease (AD). However, limited research …

Plasma amyloid-β42/40 and apolipoprotein E for amyloid PET pre-screening in secondary prevention trials of Alzheimer's disease

NC Cullen, S Janelidze, E Stomrud… - Brain …, 2023 - academic.oup.com
The extent to which newly developed blood-based biomarkers could reduce screening costs
in secondary prevention trials of Alzheimer's disease is mostly unexplored. We collected …

Current Trends and Applications of PET/MRI Hybrid Imaging in Neurodegenerative Diseases and Normal Aging

J Lee, J Renslo, K Wong, TG Clifford, BD Beutler… - Diagnostics, 2024 - mdpi.com
Dementia is a significant global health issue that is exacerbated by an aging population.
Imaging plays an established role in the evaluation of patients with neurocognitive disorders …