The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …

Abstract p73 is a structural and functional homologue of the p53 tumor suppressor protein.
Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive …

The p53 family of proteins is comprised of p53, p63 and p73. Because the p53 DNA binding
domain (DBD) is naturally unstable and possesses an amyloidogenic sequence, it is prone …

Serine/threonine phosphatases such as PP1 lack substrate specificity and associate with a
large array of targeting subunits to achieve the requisite selectivity. The tumour suppressor …

The functionality of the tumor suppressor p53 is altered in more than 50% of human cancers,
and many individuals with cancer exhibit amyloid-like buildups of aggregated p53. An …

The tumour suppressor p53 is a master sensor of stress and it controls the expression of
hundreds to thousands of genes with diverse biological functions including cell cycle arrest …

The gene encoding the p53 tumor suppressor protein, a sequence-specific DNA binding
transcription factor, is the most frequently mutated gene in human cancer. Crystal structures …

Simple Summary The p53 family of proteins comprises p53, p63, and p73, which share high
structural and functional similarity. The two distinct promoters of each locus, the alternative …

Post-transcriptional modifications at the anticodon stem-loop of tRNAs are key to the
translation function. Metabolic pathways to these modifications often incorporate complex …

Hepatitis C virus (HCV) infects millions of people worldwide and is a leading cause of liver
disease. Despite recent advances in antiviral therapies, viral resistance can limit drug …