Brain GABA levels across psychiatric disorders: A systematic literature review and meta‐analysis of 1H‐MRS studies

RR Schür, LWR Draisma, JP Wijnen… - Human brain …, 2016 - Wiley Online Library
The inhibitory gamma‐aminobutyric acid (GABA) system is involved in the etiology of most
psychiatric disorders, including schizophrenia, autism spectrum disorder (ASD) and major …

The GABAA receptor as a therapeutic target for neurodevelopmental disorders

S Braat, RF Kooy - Neuron, 2015 - cell.com
Intellectual disability, autism spectrum disorder, and epilepsy are prime examples of
neurodevelopmental disorders that collectively affect a significant percentage of the world …

Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders

L Tabouy, D Getselter, O Ziv, M Karpuj, T Tabouy… - Brain, behavior, and …, 2018 - Elsevier
Recent studies have determined that the microbiome has direct effects on behavior, and
may be dysregulated in neurodevelopmental conditions. Considering that …

A computational perspective on autism

A Rosenberg, JS Patterson… - Proceedings of the …, 2015 - National Acad Sciences
Autism is a neurodevelopmental disorder that manifests as a heterogeneous set of social,
cognitive, motor, and perceptual symptoms. This system-wide pervasiveness suggests that …

Neurometabolite levels in the brains of patients with autism spectrum disorders: A meta-analysis of proton magnetic resonance spectroscopy studies (N = 1501)

Y Du, L Chen, MC Yan, YL Wang, XL Zhong… - Molecular …, 2023 - nature.com
Evidence suggests that neurometabolite alterations may be involved in the pathophysiology
of autism spectrum disorders (ASDs). We performed a meta-analysis of proton magnetic …

Non-invasive brain stimulation for the rehabilitation of children and adolescents with neurodevelopmental disorders: a systematic review

A Finisguerra, R Borgatti, C Urgesi - Frontiers in psychology, 2019 - frontiersin.org
In the last years, there has been a growing interest in the application of different non-
invasive brain stimulation techniques to induce neuroplasticity and to modulate cognition …

Tactile hypersensitivity and GABA concentration in the sensorimotor cortex of adults with autism

LA Sapey‐Triomphe, F Lamberton, S Sonié… - Autism …, 2019 - Wiley Online Library
Sensory hypersensitivity is frequently encountered in autism spectrum disorder (ASD).
Gamma‐aminobutyric acid (GABA) has been hypothesized to play a role in tactile …

Measuring neural excitation and inhibition in autism: Different approaches, different findings and different interpretations

A Dickinson, M Jones, E Milne - Brain research, 2016 - Elsevier
The balance of neural excitation and inhibition (E/I balance) is often hypothesised to be
altered in autism spectrum disorder (ASD). One widely held view is that excitation levels are …

Sensory over-responsivity is related to GABAergic inhibition in thalamocortical circuits

ET Wood, KK Cummings, J Jung, G Patterson… - Translational …, 2021 - nature.com
Abstract Sensory over-responsivity (SOR), extreme sensitivity to or avoidance of sensory
stimuli (eg, scratchy fabrics, loud sounds), is a highly prevalent and impairing feature of …

The developmental trajectory of functional excitation‐inhibition balance relates to language abilities in autistic and allistic children

H Plueckebaum, L Meyer, AK Beck… - Autism Research, 2023 - Wiley Online Library
Autism is a neurodevelopmental condition that has been related to an overall imbalance
between the brain's excitatory (E) and inhibitory (I) systems. Such an EI imbalance can lead …