Sex differences in neuroimmune and glial mechanisms of pain
AM Gregus, IS Levine, KA Eddinger, TL Yaksh… - Pain, 2021 - journals.lww.com
Pain is the primary motivation for seeking medical care. Although pain may subside as
inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain …
inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain …
Sensory neurons, neuroimmunity, and pain modulation by sex hormones
The inclusion of women in preclinical pain studies has become more commonplace in the
last decade as the National Institutes of Health (NIH) released its “Sex as a Biological …
last decade as the National Institutes of Health (NIH) released its “Sex as a Biological …
[HTML][HTML] IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice
Although sex dimorphism is increasingly recognized as an important factor in pain, female-
specific pain signaling is not well studied. Here we report that administration of IL-23 …
specific pain signaling is not well studied. Here we report that administration of IL-23 …
A female-specific role for calcitonin gene-related peptide (CGRP) in rodent pain models
C Paige, I Plasencia-Fernandez, M Kume… - Journal of …, 2022 - Soc Neuroscience
We aimed to investigate a sexually dimorphic role of calcitonin gene-related peptide (CGRP)
in rodent models of pain. Based on findings in migraine where CGRP has a preferential pain …
in rodent models of pain. Based on findings in migraine where CGRP has a preferential pain …
Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine
M Watanabe, CM Kopruszinski, A Moutal, D Ikegami… - Brain, 2022 - academic.oup.com
Migraine headache results from activation of meningeal nociceptors, however, the
hypothalamus is activated many hours before the emergence of pain. How hypothalamic …
hypothalamus is activated many hours before the emergence of pain. How hypothalamic …
Meningeal CGRP‐prolactin interaction evokes female‐specific migraine behavior
A Avona, BN Mason, C Burgos‐Vega… - Annals of …, 2021 - Wiley Online Library
Objective Migraine is three times more common in women. CGRP plays a critical role in
migraine pathology and causes female‐specific behavioral responses upon meningeal …
migraine pathology and causes female‐specific behavioral responses upon meningeal …
Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain
The prevalence and severity of many chronic pain syndromes differ across sex, and recent
studies have identified differences in immune signalling within spinal nociceptive circuits as …
studies have identified differences in immune signalling within spinal nociceptive circuits as …
[HTML][HTML] The association between prolactin and metabolic parameters in PCOS women: a retrospective analysis
H Yang, J Di, J Pan, R Yu, Y Teng, Z Cai… - Frontiers in …, 2020 - frontiersin.org
Background: The aim of this retrospective study was to analyze the association between
prolactin (PRL) and metabolic parameters in infertile patients with polycystic ovary syndrome …
prolactin (PRL) and metabolic parameters in infertile patients with polycystic ovary syndrome …
Sex differences in nociceptor translatomes contribute to divergent prostaglandin signaling in male and female mice
Background There are clinically relevant sex differences in acute and chronic pain
mechanisms, but we are only beginning to understand their mechanistic basis …
mechanisms, but we are only beginning to understand their mechanistic basis …
Prolactin and pain of endometriosis
GJ Lee, F Porreca, E Navratilova - Pharmacology & Therapeutics, 2023 - Elsevier
Women experience chronic pain more often than men with some pain conditions being
specific to women while others are more prevalent in women. Prolactin, a neuropeptide …
specific to women while others are more prevalent in women. Prolactin, a neuropeptide …