Sex differences in neuroimmune and glial mechanisms of pain

AM Gregus, IS Levine, KA Eddinger, TL Yaksh… - Pain, 2021 - journals.lww.com
Pain is the primary motivation for seeking medical care. Although pain may subside as
inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain …

Sensory neurons, neuroimmunity, and pain modulation by sex hormones

ME Lenert, A Avona, KM Garner, LR Barron… - …, 2021 - academic.oup.com
The inclusion of women in preclinical pain studies has become more commonplace in the
last decade as the National Institutes of Health (NIH) released its “Sex as a Biological …

[HTML][HTML] IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice

X Luo, O Chen, Z Wang, S Bang, J Ji, SH Lee, Y Huh… - Neuron, 2021 - cell.com
Although sex dimorphism is increasingly recognized as an important factor in pain, female-
specific pain signaling is not well studied. Here we report that administration of IL-23 …

A female-specific role for calcitonin gene-related peptide (CGRP) in rodent pain models

C Paige, I Plasencia-Fernandez, M Kume… - Journal of …, 2022 - Soc Neuroscience
We aimed to investigate a sexually dimorphic role of calcitonin gene-related peptide (CGRP)
in rodent models of pain. Based on findings in migraine where CGRP has a preferential pain …

Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine

M Watanabe, CM Kopruszinski, A Moutal, D Ikegami… - Brain, 2022 - academic.oup.com
Migraine headache results from activation of meningeal nociceptors, however, the
hypothalamus is activated many hours before the emergence of pain. How hypothalamic …

Meningeal CGRP‐prolactin interaction evokes female‐specific migraine behavior

A Avona, BN Mason, C Burgos‐Vega… - Annals of …, 2021 - Wiley Online Library
Objective Migraine is three times more common in women. CGRP plays a critical role in
migraine pathology and causes female‐specific behavioral responses upon meningeal …

Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain

A Dedek, J Xu, LÉ Lorenzo, AG Godin… - Brain, 2022 - academic.oup.com
The prevalence and severity of many chronic pain syndromes differ across sex, and recent
studies have identified differences in immune signalling within spinal nociceptive circuits as …

[HTML][HTML] The association between prolactin and metabolic parameters in PCOS women: a retrospective analysis

H Yang, J Di, J Pan, R Yu, Y Teng, Z Cai… - Frontiers in …, 2020 - frontiersin.org
Background: The aim of this retrospective study was to analyze the association between
prolactin (PRL) and metabolic parameters in infertile patients with polycystic ovary syndrome …

Sex differences in nociceptor translatomes contribute to divergent prostaglandin signaling in male and female mice

D Tavares-Ferreira, PR Ray, I Sankaranarayanan… - Biological …, 2022 - Elsevier
Background There are clinically relevant sex differences in acute and chronic pain
mechanisms, but we are only beginning to understand their mechanistic basis …

Prolactin and pain of endometriosis

GJ Lee, F Porreca, E Navratilova - Pharmacology & Therapeutics, 2023 - Elsevier
Women experience chronic pain more often than men with some pain conditions being
specific to women while others are more prevalent in women. Prolactin, a neuropeptide …