[HTML][HTML] Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy
J Li, K Chen, X Li, X Zhang, L Zhang, Q Yang… - Cell Death …, 2023 - nature.com
In the early stages of diabetic retinopathy (DR), diabetes-related hyperglycemia directly
inhibits the AKT signaling pathway by increasing oxidative stress or inhibiting growth factor …
inhibits the AKT signaling pathway by increasing oxidative stress or inhibiting growth factor …
Nitric oxide in the pathophysiology of retinopathy: evidences from preclinical and clinical researches
R Opatrilova, P Kubatka, M Caprnda… - Acta …, 2018 - Wiley Online Library
Retinopathy is the leading cause of blindness and visual disability in working‐aged people.
The pathogenesis of retinopathy is an actual and still open query. Alterations contributing to …
The pathogenesis of retinopathy is an actual and still open query. Alterations contributing to …
Short-term high-fat feeding exacerbates degeneration in retinitis pigmentosa by promoting retinal oxidative stress and inflammation
O Kutsyr, A Noailles, N Martínez-Gil… - Proceedings of the …, 2021 - National Acad Sciences
A high-fat diet (HFD) can induce hyperglycemia and metabolic syndromes that, in turn, can
trigger visual impairment. To evaluate the acute effects of HFD feeding on retinal …
trigger visual impairment. To evaluate the acute effects of HFD feeding on retinal …
[HTML][HTML] GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions
Background Although diabetic retinopathy (DR) has long been considered as a
microvascular disorder, mounting evidence suggests that diabetic retinal …
microvascular disorder, mounting evidence suggests that diabetic retinal …
Functional deficits precede structural lesions in mice with high-fat diet–induced diabetic retinopathy
R Rajagopal, GW Bligard, S Zhang, L Yin… - Diabetes, 2016 - Am Diabetes Assoc
Obesity predisposes to human type 2 diabetes, the most common cause of diabetic
retinopathy. To determine if high-fat diet–induced diabetes in mice can model retinal …
retinopathy. To determine if high-fat diet–induced diabetes in mice can model retinal …
[HTML][HTML] Impacts of high fat diet on ocular outcomes in rodent models of visual disease
DA Clarkson-Townsend, AJ Douglass, A Singh… - Experimental eye …, 2021 - Elsevier
High fat diets (HFD) have been utilized in rodent models of visual disease for over 50 years
to model the effects of lipids, metabolic dysfunction, and diet-induced obesity on vision and …
to model the effects of lipids, metabolic dysfunction, and diet-induced obesity on vision and …
[HTML][HTML] High-fat diet induces toll-like receptor 4-dependent macrophage/microglial cell activation and retinal impairment
JJ Lee, PW Wang, IH Yang, HM Huang… - … & visual science, 2015 - iovs.arvojournals.org
Purpose.: The toll-like receptor 4 (TLR4) signaling pathway is involved in chronic
inflammation and insulin resistance, which are associated with obesity and diabetes …
inflammation and insulin resistance, which are associated with obesity and diabetes …
Unconventional avenues to decelerate diabetic retinopathy
B Takkar, A Sheemar, R Jayasudha, D Soni… - Survey of …, 2022 - Elsevier
Diabetic retinopathy (DR) is an important microvascular complication of diabetes mellitus
(DM), causing significant visual impairment worldwide. Current gold standards for retarding …
(DM), causing significant visual impairment worldwide. Current gold standards for retarding …
[HTML][HTML] Vitamin A as a key regulator of obesity & its associated disorders: Evidences from an obese rat model
SM Jeyakumar, A Vajreswari - Indian journal of medical research, 2015 - journals.lww.com
During the last century, vitamin A has evolved from its classical role as a fat-soluble vitamin
and attained the status of para-/autocrine hormone. Besides its well-established role in …
and attained the status of para-/autocrine hormone. Besides its well-established role in …
[HTML][HTML] Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression
The incidence of type 2 diabetes, the most common cause of diabetic retinopathy (DR), is
rapidly on the rise in developed countries due to overconsumption of calorie rich diets …
rapidly on the rise in developed countries due to overconsumption of calorie rich diets …