Structures and general transport mechanisms by the major facilitator superfamily (MFS)
The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …
transporters. MFS transporters are responsible for transporting a broad spectrum of …
MalDA, accelerating malaria drug discovery
The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories.
The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process …
The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process …
Cryo-EM structure of human glucose transporter GLUT4
GLUT4 is the primary glucose transporter in adipose and skeletal muscle tissues. Its cellular
trafficking is regulated by insulin signaling. Failed or reduced plasma membrane localization …
trafficking is regulated by insulin signaling. Failed or reduced plasma membrane localization …
Molecular basis for substrate recognition and transport of human GABA transporter GAT1
A Zhu, J Huang, F Kong, J Tan, J Lei, Y Yuan… - Nature Structural & …, 2023 - nature.com
Abstract γ-Aminobutyric acid (GABA), an important inhibitory neurotransmitter in the central
nervous system, is recycled through specific GABA transporters (GATs). GAT1, which is …
nervous system, is recycled through specific GABA transporters (GATs). GAT1, which is …
Establishing mammalian GLUT kinetics and lipid composition influences in a reconstituted-liposome system
A Suades, A Qureshi, SE McComas, M Coinçon… - Nature …, 2023 - nature.com
Glucose transporters (GLUTs) are essential for organism-wide glucose homeostasis in
mammals, and their dysfunction is associated with numerous diseases, such as diabetes …
mammals, and their dysfunction is associated with numerous diseases, such as diabetes …
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank
Biological membranes define the boundaries of cells and compartmentalize the chemical
and physical processes required for life. Many biological processes are carried out by …
and physical processes required for life. Many biological processes are carried out by …
Molecular basis for inhibiting human glucose transporters by exofacial inhibitors
Human glucose transporters (GLUTs) are responsible for cellular uptake of hexoses.
Elevated expression of GLUTs, particularly GLUT1 and GLUT3, is required to fuel the …
Elevated expression of GLUTs, particularly GLUT1 and GLUT3, is required to fuel the …
Reconstructing the transport cycle in the sugar porter superfamily using coevolution-powered machine learning
D Mitrovic, SE McComas, C Alleva, M Bonaccorsi… - Elife, 2023 - elifesciences.org
Sugar porters (SPs) represent the largest group of secondary-active transporters. Some
members, such as the glucose transporters (GLUTs), are well known for their role in …
members, such as the glucose transporters (GLUTs), are well known for their role in …
Trends of antimalarial marine natural products: Progresses, challenges and opportunities
Y Hai, ZM Cai, PJ Li, MY Wei, CY Wang, YC Gu… - Natural Product …, 2022 - pubs.rsc.org
Covering 1972 to 2021 Malaria remains a significant public health problem in some regions
of the world. The great efforts to control malaria have been severely compromised due to the …
of the world. The great efforts to control malaria have been severely compromised due to the …
Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38
JF Armstrong, B Campo, SPH Alexander… - British Journal of …, 2023 - Wiley Online Library
Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic
cellular screening, allowing millions of compounds to be assayed and delivering clinical …
cellular screening, allowing millions of compounds to be assayed and delivering clinical …