Diabetic nephropathy is the leading cause of end‐stage kidney disease worldwide but
current treatments remain suboptimal. This review examines the evidence for inflammation …

Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …

Inflammation significantly contributes to the progression of chronic kidney disease (CKD).
Inflammasome-dependent cytokines, such as IL-1β and IL-18, play a role in CKD, but their …

Activated fibroblasts promote physiological wound repair following tissue injury. However,
dysregulation of fibroblast activation contributes to the development of fibrosis by enhanced …

Post-breeding endometritis (ie, inflammation/infection of the endometrium), is a
physiological reaction taking place in the endometrium of mares within 48 h post-breeding …

Renal inflammation is a universal response to infectious and noninfectious triggers. Sensors
of the innate immune system, such as Toll-like receptors or RIG-like receptors, provide …

Different types of activated leukocytes play a crucial role in the pathogenesis of most kidney
diseases from acute to chronic stages; however, diabetic nephropathy was not considered …

Abstract Interleukin-1 receptor-associated kinases (IRAK1, IRAK2, IRAK3 [IRAK-M], and
IRAK4) are serine-threonine kinases involved in toll-like receptor and interleukin-1 signaling …

The NLRP3 inflammasome is activated by mitochondrial damage and contributes to kidney
fibrosis. However, it is unknown whether PGC-1α, a key mitochondrial biogenesis regulator …

Diabetic nephropathy is a leading cause of end-stage renal failure and is a growing concern
given the increasing incidence of type 2 diabetes. Diabetic nephropathy is associated with …