Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …

The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

The past few decades have generated growing recognition that the immune system makes
an important contribution to cardiac development, composition and function. Immune cells …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

Expansion and activation of fibroblasts following cardiac injury is important for repair but
may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the …

Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …

Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen.
Myofibroblasts are major players in the production of collagen, and are differentiated …

Myocardial infarction triggers an intense inflammatory response that is essential for cardiac
repair, but which is also implicated in the pathogenesis of postinfarction remodelling and …

Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the
cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many …