Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

The molecular composition of the cell wall is critical for the biology and ecology of each
fungal species. Fungal walls are composed of matrix components that are embedded and …

Various diseases remain untreated due to lack of suitable therapeutic moiety or a suitable
drug delivery device, especially where toxicities and side effects are the primary reason for …

The utility of clinically available antifungals is limited by their narrow spectrum of activity,
high toxicity, and emerging resistance. Antifungal drug discovery has always been a …

Despite the substantial global burden of human fungal infections, there are no approved
fungal vaccines to protect at risk individuals. Here, we review the progress that has been …

Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger
intracellular signaling cascades that initiate and direct innate and adaptive immune …

Recent technological advances in glycobiology and glycochemistry are paving the way for a
new era in carbohydrate vaccine design. This is enabling greater efficiency in the …

The need for better antifungal therapy is commonly accepted in view of the high mortality
rates associated with systemic infections, the low number of available antifungal classes …

Fungal infections include a wide range of opportunistic and invasive diseases. Two of four
major fatal diseases in patients with human immunodeficiency virus (HIV) infection are …

Cell surface carbohydrates have been proven optimal targets for vaccine development.
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …