[HTML][HTML] Adipose-tissue plasticity in health and disease
Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …
organ. While historically viewed as a passive site for energy storage, we now appreciate that …
Gut microbiota-derived metabolites as central regulators in metabolic disorders
Metabolic disorders represent a growing worldwide health challenge due to their
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …
The cellular and functional complexity of thermogenic fat
P Cohen, S Kajimura - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …
in the form of heat. These thermogenic fat cells were originally considered to function solely …
[HTML][HTML] Diabetic vascular diseases: molecular mechanisms and therapeutic strategies
Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …
treatment protocols based on a single vascular complication are no longer suitable for the …
[HTML][HTML] Brown-fat-mediated tumour suppression by cold-altered global metabolism
T Seki, Y Yang, X Sun, S Lim, S Xie, Z Guo, W Xiong… - Nature, 2022 - nature.com
Glucose uptake is essential for cancer glycolysis and is involved in non-shivering
thermogenesis of adipose tissues,,,,–. Most cancers use glycolysis to harness energy for …
thermogenesis of adipose tissues,,,,–. Most cancers use glycolysis to harness energy for …
[HTML][HTML] Amino acids in cancer
Abstract Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis
established metabolic reprogramming as one of the first distinguishing characteristics of …
established metabolic reprogramming as one of the first distinguishing characteristics of …
[HTML][HTML] Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 …
F Vanweert, P Schrauwen, E Phielix - Nutrition & diabetes, 2022 - nature.com
Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells
Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key
roles in oxidative metabolism. Mitochondria, as the major site of oxidative reactions, must …
roles in oxidative metabolism. Mitochondria, as the major site of oxidative reactions, must …
Branched-chain amino acids in cardiovascular disease
RW McGarrah, PJ White - Nature Reviews Cardiology, 2023 - nature.com
Research conducted in the past 15 years has yielded crucial insights that are reshaping our
understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism …
understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism …
[HTML][HTML] Insulin action, type 2 diabetes, and branched-chain amino acids: a two-way street
Background A strong association of obesity and insulin resistance with increased circulating
levels of branched-chain and aromatic amino acids and decreased glycine levels has been …
levels of branched-chain and aromatic amino acids and decreased glycine levels has been …