Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Certain morphological, physiological and molecular characteristics are shared by all
neurons. However, despite these similarities, neurons constitute the most diverse cell …

Direct lineage reprogramming is a promising approach for human disease modeling and
regenerative medicine, with poorly understood mechanisms. Here, we reveal a hierarchical …

Neural progenitors of the vertebrate CNS are defined by generic cellular characteristics,
including their pseudoepithelial morphology and their ability to divide and differentiate …

Normal differentiation and induced reprogramming require the activation of target cell
programs and silencing of donor cell programs,. In reprogramming, the same factors are …

The NEUROGENINS (NGNs) are neural-specific basic helix–loop–helix (bHLH) transcription
factors. Mouse embryos lacking ngn1 fail to generate the proximal subset of cranial sensory …

Targeted gene expression is a powerful approach to study the function of genes and cells in
vivo. In Drosophila, the P element-mediated Gal4-UAS method has been successfully used …

The hematopoietic transcription factor GATA-1 is essential for development of the erythroid
and megakaryocytic lineages. Using the conserved zinc finger DNA-binding domain of …

In vertebrates, the delineation of the neural plate from a region of the primitive ectoderm is
accompanied by the onset of specific gene expression which in turn promotes the formation …

For decades, Waddington's concept of the'epigenetic landscape'has served as an educative
hierarchical model to illustrate the progressive restriction of cell differentiation potential …