Cell-free protein synthesis: a promising option for future drug development

SK Dondapati, M Stech, A Zemella, S Kubick - BioDrugs, 2020 - Springer
Proteins are the main source of drug targets and some of them possess therapeutic potential
themselves. Among them, membrane proteins constitute approximately 50% of the major …

Gene-by-gene screen of the unknown proteins encoded on Plasmodium falciparum chromosome 3

J Kimmel, M Schmitt, A Sinner, PWTC Jansen… - Cell Systems, 2023 - cell.com
Taxon-specific proteins are key determinants defining the biology of all organisms and
represent prime drug targets in pathogens. However, lacking comparability with proteins in …

Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite Plasmodium falciparum

JS Wichers, J Wunderlich, D Heincke… - Cellular …, 2021 - Wiley Online Library
The inner membrane complex (IMC) is a defining feature of apicomplexan parasites, which
confers stability and shape to the cell, functions as a scaffolding compartment during the …

Contriving a novel multi-epitope subunit vaccine from Plasmodium falciparum vaccine candidates against malaria

CO Mamudu, FN Iheagwam, EO Okafor… - Journal of Applied …, 2024 - japsonline.com
In this study, immunoinformatics strategies were used to design a subunit vaccine against
malaria from immunogenic regions of three Plasmodium falciparum surface antigens; liver …

Sistemas de expresión de proteínas recombinantes para el análisis funcional de antígenos de Plasmodium falciparum y Plasmodium vivax: una revisión

AM Gómez-Rodríguez… - Revista …, 2021 - revistasdigitales.uniboyaca.edu.co
Introducción: Para diseñar vacunas es necesario comprender la función de los antígenos de
Plasmodium spp. involucrados en la invasión a células hospederas. Diferentes …

[PDF][PDF] Potensi Vaksin Antibodi Anti-PfRH5 Berbasis Nanopartikel Liposom sebagai Modalitas Preventif Mutakhir pada Plasmodium falciparum Malaria

ABS Satyarsa, F Sanjaya, NM Gitari - Indonesian Journal of …, 2020 - researchgate.net
Plasmodium falciparum malaria dalah salah satu penyakit infeksi yang disebabkan oleh
parasit protozoa Plasmodium falciparum dengan morbiditas dan mortalitas terbesar kasus …

High-throughput profiling of natural acquired humoral immune response to a large panel of known and novel full length ectodomain P. falciparum merozoite vaccine …

DN Ndungu, J Tuju, E Chepsat, R Mwai, K Mwai… - bioRxiv, 2022 - biorxiv.org
Despite recent progress in the fight against malaria, it still remains a global health challenge
necessitating development of intervention strategies. However, the search for malaria …

[PDF][PDF] Sistemas de expresión de proteínas recombinantes para el análisis funcional de antígenos de Plasmodium falciparum y Plasmodium vivax: una revisión

GRÁ Marcela, CCL Esperanza, CMA Jineth - scholar.archive.org
Introducción. Comprender la función de antígenos de Plasmodium spp., involucrados en
invasión a células hospederas es necesario para diseñar vacunas. Diferentes estudios han …

The expression of PF3D7_1146100; a novel, essential Plasmodium falciparum antigen, and its evaluation as a target of protective immunity to clinical malaria.

FK Marura - 2021 - erepository.uonbi.ac.ke
The use of reverse vaccinology in vaccine candidate antigen discovery has led to
identification of many Plasmodium falciparum novel antigens. Some of these antigens are …

Functional Characterisation Of Novel Plasmodium falciparum Proteins And Their Role In Erythrocyte Invasion

B Liffner - 2020 - digital.library.adelaide.edu.au
Malaria caused by Plasmodium falciparum is responsible for the deaths of hundreds of
thousands of children every year, and imparts an overwhelming economic burden on the …