[HTML][HTML] Immunoglobulin G glycosylation in aging and diseases
Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …
a significant degree of variation within populations. IgG glycome composition is influenced …
Glycans as cancer biomarkers
B Adamczyk, T Tharmalingam, PM Rudd - Biochimica et Biophysica Acta …, 2012 - Elsevier
BACKGROUND: Non-invasive biomarkers, such as those from serum, are ideal for disease
prognosis, staging and monitoring. In the past decade, our understanding of the importance …
prognosis, staging and monitoring. In the past decade, our understanding of the importance …
High-sensitivity analytical approaches for the structural characterization of glycoproteins
1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …
propensity to form varied linkages, substitutions, and branching patterns have fascinated …
[HTML][HTML] Aberrant protein glycosylation: Implications on diagnosis and Immunotherapy
Glycosylation-mediated post-translational modification is critical for regulating many
fundamental processes like cell division, differentiation, immune response, and cell-to-cell …
fundamental processes like cell division, differentiation, immune response, and cell-to-cell …
Haptoglobin: From hemoglobin scavenging to human health
A di Masi, G De Simone, C Ciaccio, S D'Orso… - Molecular Aspects of …, 2020 - Elsevier
Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …
Recent advances in hydrophilic interaction liquid chromatography (HILIC) for structural glycomics
This review presents recent progress in employing hydrophilic interaction liquid
chromatography (HILIC) for glycan and glycopeptides analysis. After an introduction of this …
chromatography (HILIC) for glycan and glycopeptides analysis. After an introduction of this …
Serum sialylation changes in cancer
Cancer is a major cause of death in both developing and developed countries. Early
detection and efficient therapy can greatly enhance survival. Aberrant glycosylation has …
detection and efficient therapy can greatly enhance survival. Aberrant glycosylation has …
N-linked glycan structures and their expressions change in the blood sera of ovarian cancer patients
WR Alley Jr, JA Vasseur, JA Goetz… - Journal of proteome …, 2012 - ACS Publications
Glycosylated proteins play important roles in a broad spectrum of biochemical and biological
processes, and prior reports have suggested that changes in protein glycosylation occur …
processes, and prior reports have suggested that changes in protein glycosylation occur …
N-glycosylation of colorectal cancer tissues: a liquid chromatography and mass spectrometry-based investigation
CIA Balog, K Stavenhagen, WLJ Fung… - Molecular & Cellular …, 2012 - ASBMB
Colorectal cancer is the third most common cancer worldwide with an annual incidence of∼
1 million cases and an annual mortality rate of∼ 655,000 individuals. There is an urgent …
1 million cases and an annual mortality rate of∼ 655,000 individuals. There is an urgent …
Biosynthetic machinery involved in aberrant glycosylation: promising targets for developing of drugs against cancer
A Vasconcelos-dos-Santos, IA Oliveira… - Frontiers in …, 2015 - frontiersin.org
Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the
malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose …
malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose …