Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …

BACKGROUND: Non-invasive biomarkers, such as those from serum, are ideal for disease
prognosis, staging and monitoring. In the past decade, our understanding of the importance …

1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …

Glycosylation-mediated post-translational modification is critical for regulating many
fundamental processes like cell division, differentiation, immune response, and cell-to-cell …

Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …

This review presents recent progress in employing hydrophilic interaction liquid
chromatography (HILIC) for glycan and glycopeptides analysis. After an introduction of this …

Cancer is a major cause of death in both developing and developed countries. Early
detection and efficient therapy can greatly enhance survival. Aberrant glycosylation has …

Glycosylated proteins play important roles in a broad spectrum of biochemical and biological
processes, and prior reports have suggested that changes in protein glycosylation occur …

Colorectal cancer is the third most common cancer worldwide with an annual incidence of∼
1 million cases and an annual mortality rate of∼ 655,000 individuals. There is an urgent …

Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the
malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose …