Cancer cells proliferate, differentiate and migrate by repurposing physiological signalling
mechanisms. In particular, altered calcium signalling is emerging as one of the most …

Almost three decades have passed since the identification of the two specific metabotropic
receptors mediating cannabinoid pharmacology. Thereafter, many cannabinoid effects, both …

Metastasis is the hallmark of failed tumor treatment and is typically associated with death
due to cancer. Transient receptor potential (TRP) channels affect changes in intracellular …

The transient melastatin receptor potential (TRPM) ion channel subfamily functions as
cellular sensors and transducers of critical biological signal pathways by regulating ion …

Abstract Transient Receptor Potential (TRP) family mediate the influx of monovalent and/or
divalent cations into cells in response to environmental stimuli. Pharmacological or genetic …

HOXB13, a homeodomain transcription factor, is linked to recurrence following radical
prostatectomy. While HOXB13 regulates Androgen Receptor (AR) functions in a context …

Therapy resistance is a major roadblock in oncology. Exacerbation of molecular
dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms …

Abstract Holliday Junction Recognition Protein (HJURP) is a centromeric histone chaperone
involving in de novo histone H3 variant CenH3 (CENP-A) recruitment. Our transcriptome …

In the fight against prostate cancer (PCa), TRPM8 is one of the most promising clinical
targets. Indeed, several studies have highlighted that TRPM8 involvement is key in PCa …

Prostate cancer (PCa) is one of the most frequently diagnosed cancers in developed
countries. Several studies suggest that variations in calcium homeostasis are involved in …