In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

The pathogenesis of type 2 diabetes is complex and in most instances clearly requires
defects in both ß-cell function and insulin sensitivity (1). Together, these abnormalities result …

THE 37-amino-acid polypeptide amylin is the principal constituent of the amyloid deposits
that form in the islets of Langerhans in patients with type-2 diabetes mellitus1–5, but its role …

This review summarizes the receptor-mediated vascular activities of calcitonin gene-related
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …

Abstract Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin
secretion, loss of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet …

Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these deposits
contain the unique amyloidogenic peptide islet amyloid polypeptide. Autopsy studies in …

Islet amyloid polypeptide (IAPP) has been identified as the major constituent of the
pancreatic amyloid of non-insulin-dependent diabetes mellitus (NIDDM) and is also present …

Islet amyloid has been recognized as a pathological entity in type 2 diabetes since the turn
of the century. It has as its unique component the islet beta-cell peptide islet amyloid …

VAN ROSSUM, DU-K. HANISCH AND R. QUIRION. Neuroanatomical localization,
pharmacological characterization and functions of CGRP, related peptides and their …

Amylin is a 37-amino acid cytotoxic constituent of amyloid deposits found in the islets of
Langerhans of patients with type II diabetes. Extracellular accumulation of this peptide …