Epithelial mesenchymal transition (EMT) and mesenchymal epithelial transition (MET) are
genetic determinants of cellular plasticity. These programs operate in physiological …

▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …

The helix-loop-helix (HLH) family of transcriptional regulatory proteins are key players in a
wide array of developmental processes. Over 240 HLH proteins have been identified to date …

The state of chromatin (the packaging of DNA in eukaryotes) has long been recognized to
have major effects on levels of gene expression, and numerous chromatin-altering …

CREB binding protein (CBP) and p300 were both identified initially in protein interaction
assays–the former through its association with the transcription factor CREB (Chrivia et al …

Nuclear receptors (NR) comprise a family of transcription factors that regulate gene
expression in a liganddependent manner. Members of the NR superfamily include receptors …

This article reviews the molecular structure, expression pattern, physiological function,
pathological roles and molecular mechanisms of Twist1 in development, genetic disease …

p300/CBP transcriptional co-activator proteins play a central role in co-ordinating and
integrating multiple signal-dependent events with the transcription apparatus, allowing the …

The fact that histones are modified by acetylation has been known for almost 30 years. The
recent identification of enzymes that regulate histone acetylation has revealed a broader use …

The nuclear function of the heterodimeric NF‐κB transcription factor is regulated in part
through reversible acetylation of its RelA subunit. We now demonstrate that the p300 and …