Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum …

Alzheimer's disease (AD) is an age-related dementia and neurodegenerative disorder,
characterized by Aβ and tau protein deposition impairing learning, memory and suppressing …

Spatial transcriptomic technologies and spatially annotated single-cell RNA sequencing
datasets provide unprecedented opportunities to dissect cell–cell communication (CCC) …

In the last several years a large number of studies have demonstrated the neurobiological
and clinical continuum between depression and Alzheimer's disease (AD). Depression is a …

Alzheimer9s disease (AD) is characterized by progressive cognitive decline, increasingly
attributed to neuronal dysfunction induced by amyloid-β oligomers (AβOs). Although the …

An increasing number of studies show that both inflammation and neural plasticity act as key
players in the vulnerability and recovery from psychiatric disorders and neurodegenerative …

Transforming growth factor betas (TGF-βs) are known as multifunctional growth factors that
participate in the regulation of key events of development, disease, and tissue repair. In the …

The neurotrophic hypothesis of depression proposes that reduced levels of brain-derived
neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) contribute to …

The expeditious advancement of Alzheimer's Disease (AD) is a threat to the global
healthcare system, that is further supplemented by therapeutic failure. The prevalence of this …

Carnosine is a natural endogenous dipeptide widely distributed in mammalian tissues,
existing at particularly high concentrations in the muscles and brain and possesses well …