Atopic dermatitis: pathophysiology

W David Boothe, JA Tarbox, MB Tarbox - Management of atopic dermatitis …, 2017 - Springer
The pathophysiology of atopic dermatitis is complex and multifactorial, involving elements of
barrier dysfunction, alterations in cell mediated immune responses, IgE mediated …

Atopic dermatitis: Role of the skin barrier, environment, microbiome, and therapeutic agents

T Luger, M Amagai, B Dreno, MA Dagnelie… - Journal of …, 2021 - Elsevier
Atopic dermatitis (AD) is a chronic, inflammatory skin disorder characterized by eczematous
and pruritic skin lesions. In recent decades, the prevalence of AD has increased worldwide …

[HTML][HTML] Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor

A Uberoi, C Bartow-McKenney, Q Zheng, L Flowers… - Cell host & …, 2021 - cell.com
The epidermis forms a barrier that defends the body from desiccation and entry of harmful
substances, while also sensing and integrating environmental signals. The tightly …

Nanostructured lipid carriers: Promising drug delivery systems for future clinics

A Beloqui, MÁ Solinís, A Rodríguez-Gascón… - … , biology and medicine, 2016 - Elsevier
During the past decade, the number of studies describing nanostructured lipid carriers
(NLCs)-based formulations has been dramatically increased. The raise in NLC exploitation …

Atopic dermatitis in diverse racial and ethnic groups—variations in epidemiology, genetics, clinical presentation and treatment

BP Kaufman, E Guttman‐Yassky… - Experimental …, 2018 - Wiley Online Library
Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects diverse ethnic
groups with varying prevalence. Despite a predominance of studies in individuals of …

The IL-4, IL-13 and IL-31 pathways in atopic dermatitis

C Dubin, E Del Duca… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a
complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier …

[HTML][HTML] The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming

SL Prescott, DL Larcombe, AC Logan, C West… - World Allergy …, 2017 - Springer
Skin barrier structure and function is essential to human health. Hitherto unrecognized
functions of epidermal keratinocytes show that the skin plays an important role in adapting …

Environmental risk factors and their role in the management of atopic dermatitis

R Kantor, JI Silverberg - Expert review of clinical immunology, 2017 - Taylor & Francis
Introduction: The etiology of atopic dermatitis (AD) is multifactorial with interaction between
genetics, immune and environmental factors. Areas covered: We review the role of prenatal …

Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare

KR Chng, ASL Tay, C Li, AHQ Ng, J Wang, BK Suri… - Nature …, 2016 - nature.com
Whole metagenome analysis has the potential to reveal functional triggers of skin diseases,
but issues of cost, robustness and sampling efficacy have limited its application. Here, we …

Atopic dermatitis: a disease of altered skin barrier and immune dysregulation

M Boguniewicz, DYM Leung - Immunological reviews, 2011 - Wiley Online Library
Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that
often precedes asthma and allergic disorders. New insights into the genetics and …