Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first
examples were reported 18 years ago by Akiyama and Terada. Although they were …

The Biginelli reaction, involving a three-component reaction of an aromatic aldehyde, urea
and ethyl acetoacetate, has emerged as an extremely useful synthetic tool to organic …

This work describes new chiral task-specific ionic liquids bearing chiral anions as the
catalysts for the enantioselective multicomponent Biginelli reaction. For the first time, the …

A series of MCM-41 supported functionalized ionic liquids doped with copper species were
prepared, characterized and evaluated as catalysts in the Biginelli reaction. Most of these …

A covalently cross‐linked graphene oxide (GO) as a catalyst was prepared by a cross‐
linking process using the nucleophilic reaction of zirconium (IV)‐coordinated 5, 10, 15, 20 …

The reactivity of aldehydes and ketones carries great potential for multicomponent
heterocyclizations. These reactions are convergent and highly versatile in the development …

In summary, this paper describes synthesis of a new acidic catalyst to accomplish highly
enantioselective Biginelli reactions. Sulfonic-functionalized hyperbranched polylysine …

Pyrimidine heterocycles are proven to be biologically active heterocycles, found in many
biological systems, displaying a broad spectrum of biological activities including anticancer …

Different results were generated under different reaction conditions for the multicomponent
reactions. Herein, an efficiently improved and mild protocol for the synthesis of …

Biginelli adducts, also known as dihydropyrimidin-2 (1H)-ones/-thiones (DHMPs), exhibit
versatile biological activities. Among them, monastrol has gained significant popularity as an …