The many faces of the helix-turn-helix domain: transcription regulation and beyond
The helix-turn-helix (HTH) domain is a common denominator in basal and specific
transcription factors from the three super-kingdoms of life. At its core, the domain comprises …
transcription factors from the three super-kingdoms of life. At its core, the domain comprises …
Selenoproteins in Archaea and Gram-positive bacteria
T Stock, M Rother - Biochimica et Biophysica Acta (BBA)-General Subjects, 2009 - Elsevier
Selenium is an essential trace element for many organisms by serving important catalytic
roles in the form of the 21st co-translationally inserted amino acid selenocysteine. It is mostly …
roles in the form of the 21st co-translationally inserted amino acid selenocysteine. It is mostly …
The pathway to GTPase activation of elongation factor SelB on the ribosome
In all domains of life, selenocysteine (Sec) is delivered to the ribosome by selenocysteine-
specific tRNA (tRNASec) with the help of a specialized translation factor, SelB in bacteria …
specific tRNA (tRNASec) with the help of a specialized translation factor, SelB in bacteria …
Structural basis for recognition and sequestration of UUUOH 3′ temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen
The nuclear phosphoprotein La was identified as an autoantigen in patients with systemic
lupus erythematosus and Sjogren's syndrome. La binds to and protects the UUU OH 3 …
lupus erythematosus and Sjogren's syndrome. La binds to and protects the UUU OH 3 …
Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch
The La protein is a ubiquitous nuclear phosphoprotein that recognizes the 3′ uridylates
found in all newly synthesized RNA polymerase III transcripts. La binding stabilizes these …
found in all newly synthesized RNA polymerase III transcripts. La binding stabilizes these …
De novo computational RNA modeling into cryo-EM maps of large ribonucleoprotein complexes
Increasingly, cryo-electron microscopy (cryo-EM) is used to determine the structures of RNA–
protein assemblies, but nearly all maps determined with this method have biologically …
protein assemblies, but nearly all maps determined with this method have biologically …
Selenocysteine tRNA‐specific elongation factor SelB is a structural chimaera of elongation and initiation factors
M Leibundgut, C Frick, M Thanbichler, A Böck… - The EMBO …, 2005 - embopress.org
In all three kingdoms of life, SelB is a specialized translation elongation factor responsible
for the cotranslational incorporation of selenocysteine into proteins by recoding of a UGA …
for the cotranslational incorporation of selenocysteine into proteins by recoding of a UGA …
The many levels of control on bacterial selenoprotein synthesis
S Yoshizawa, A Böck - Biochimica et Biophysica Acta (BBA)-General …, 2009 - Elsevier
Selenium shares many chemical facets with sulphur but differs from it in the redox potential,
especially of the Se2−/S2− oxidation state. The higher chemical reactivity of the …
especially of the Se2−/S2− oxidation state. The higher chemical reactivity of the …
Sampling native-like structures of RNA-protein complexes through Rosetta folding and docking
RNA-protein complexes underlie numerous cellular processes including translation,
splicing, and posttranscriptional regulation of gene expression. The structures of these …
splicing, and posttranscriptional regulation of gene expression. The structures of these …
The physiology and evolution of microbial selenium metabolism
Selenium is an essential trace element whose compounds are widely metabolized by
organisms from all three domains of life. Moreover, phylogenetic evidence indicates that …
organisms from all three domains of life. Moreover, phylogenetic evidence indicates that …