Research conducted in the past 15 years has yielded crucial insights that are reshaping our
understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism …

Branched chain amino acids (BCAAs), leucine, isoleucine and valine, are essential amino
acids widely studied for their crucial role in the regulation of protein synthesis mainly through …

Protein-restricted diets promote health and longevity in many species. While the precise
components of a protein-restricted diet that mediate the beneficial effects to longevity have …

Branched chain amino acids (BCAA: leucine, valine, isoleucine) have key physiological
roles in the regulation of protein synthesis, metabolism, food intake and aging. Many studies …

This systematic review appraised previous findings on differential gut microbiota
composition and intestinal permeability markers between frail and healthy older adults. A …

The proportion of humans suffering from age‐related diseases is increasing around the
world, and creative solutions are needed to promote healthy longevity. Recent work has …

The prevalence of obesity is a worldwide phenomenon in all age groups and is associated
with aging-related diseases such as type 2 diabetes, as well metabolic and cardiovascular …

Background Frailty development is partly dependent on multiple factors like low levels of
nutrients and high levels of oxidative stress (OS) and inflammation potentially leading to a …

Branched-chain amino acids (BCAAs; a mixture of leucine, valine and isoleucine) have
important regulatory effects on glucose and lipid metabolism, protein synthesis and …

Background and aims We conducted a systematic review with meta-analysis of non-
prospective and prospective clinical studies to assess the effects of circulating branched …