Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …
Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications
S Takahashi - Journal of hematology & oncology, 2011 - Springer
FLT3 is a type III receptor tyrosine kinase. Mutations of FLT3 comprise one of the most
frequently identified types of genetic alterations in acute myeloid leukemia. One-third of …
frequently identified types of genetic alterations in acute myeloid leukemia. One-third of …
Essential role of Plzf in maintenance of spermatogonial stem cells
Little is known of the molecular mechanisms whereby spermatogonia, mitotic germ cells of
the testis, self-renew and differentiate into sperm,. Here we show that Zfp145, encoding the …
the testis, self-renew and differentiate into sperm,. Here we show that Zfp145, encoding the …
Plzf is required in adult male germ cells for stem cell self-renewal
FW Buaas, AL Kirsh, M Sharma, DJ McLean… - Nature …, 2004 - nature.com
Adult germline stem cells are capable of self-renewal, tissue regeneration and production of
large numbers of differentiated progeny. We show here that the classical mouse mutant …
large numbers of differentiated progeny. We show here that the classical mouse mutant …
The 8; 21 translocation in leukemogenesis
LF Peterson, DE Zhang - Oncogene, 2004 - nature.com
A common chromosomal translocation in acute myeloid leukemia (AML) involves the AML1
(acute myeloid leukemia 1, also called RUNX1, core binding factor protein (CBFα), and …
(acute myeloid leukemia 1, also called RUNX1, core binding factor protein (CBFα), and …
All in the family: the BTB/POZ, KRAB, and SCAN domains
T Collins, JR Stone, AJ Williams - Molecular and cellular biology, 2001 - Am Soc Microbiol
Understanding the mechanisms by which specific genes are expressed in a temporal or
tissue-specific manner is a central problem in biology. Transcription factors play a key role in …
tissue-specific manner is a central problem in biology. Transcription factors play a key role in …
VDUP1 upregulated by TGF-β1 and 1, 25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression
SH Han, JH Jeon, HR Ju, U Jung, KY Kim, HS Yoo… - Oncogene, 2003 - nature.com
Vitamin D 3 upregulated protein 1 (VDUP1) is a 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D
3) upregulated protein, and it is induced by various stresses. In human tumor tissues …
3) upregulated protein, and it is induced by various stresses. In human tumor tissues …
The c‐myc promoter: still MysterY and challenge
I Wierstra, J Alves - Advances in cancer research, 2008 - Elsevier
The transcription factor c‐Myc is a key regulator of cell proliferation, cell growth,
differentiation, and apoptosis. Deregulated c‐myc expression possesses a high …
differentiation, and apoptosis. Deregulated c‐myc expression possesses a high …
Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors
A Melnick, G Carlile, KF Ahmad, CL Kiang… - … and cellular biology, 2002 - Am Soc Microbiol
The PLZF (promyelocytic leukemia zinc finger) transcriptional repressor, when fused to
retinoic acid receptor alpha (RARα), causes a refractory form of acute promyelocytic …
retinoic acid receptor alpha (RARα), causes a refractory form of acute promyelocytic …
Translocations of the RARα gene in acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) has been recognized as a distinct clinical entity for over
40 years. Although relatively rare among hematopoietic malignancies (approximately 10 …
40 years. Although relatively rare among hematopoietic malignancies (approximately 10 …