Several chemicals, including environmental toxicants and clinically useful drugs, cause
severe cellular damage to different organs of our body through metabolic activation to highly …

The increasing global prevalence of type 2 diabetes mellitus (T2DM) and chronic kidney
disease (CKD) has prompted research efforts to tackle the growing epidemic of diabetic …

Candidiasis has increased substantially worldwide over recent decades and is a significant
cause of morbidity and mortality, especially among critically ill patients. Diabetes mellitus …

Renal fibrosis is the histological manifestation of a progressive, usually irreversible process
causing chronic and end-stage kidney disease. We performed genome-wide transcriptome …

Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the
underlying mechanism and its pathogenic role remain elusive. We show that autophagy was …

Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide and the
single strongest predictor of mortality in patients with diabetes. DKD is a prototypical disease …

The gastrointestinal tract—the largest endocrine network in human physiology—
orchestrates signals from the external environment to maintain neural and hormonal control …

Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …

Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous,
and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate …

Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic
options for preventing its progression are limited. To identify novel therapeutic strategies, we …