The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Profilin is a ubiquitously expressed protein well known as a key regulator of actin
polymerisation. The actin cytoskeleton is involved in almost all cellular processes including …

This review covers aspects of cofilin and profilin regulations and their influence on actin
polymerisation responsible for cell motility and metastasis. The regulation of their activity by …

Reactive oxygen species (ROS) are acknowledged generally to be multi-faceted regulators
of cellular functions that trigger various pathological states when present chronically or …

Aims: To examine the causes of variability in the effect of maternal drinking on the foetus,
with particular reference to the pattern, frequency and duration of the period of drinking …

Nitric oxide (NO) in plant cell mediates processes of growth and development starting from
seed germination to pollination, as well as biotic and abiotic stress tolerance. However …

Nitrosative modifications regulate cellular signal transduction and pathogenesis of
inflammatory responses and neuro-degenerative diseases. Protein tyrosine nitration is a …

The placenta plays a major role in embryo-fetal defects and intrauterine growth retardation
after maternal alcohol consumption. Our aims were to determine the oxidative status and …

Cathepsin X, a cysteine carboxypeptidase, is upregulated in several types of cancer. Its
molecular target in tumor cells is profilin 1, a known tumor suppressor and regulator of actin …

Background Profilins are actin-modulating proteins regulating many intracellular functions
based on their multiple and diverse ligand interactions. They have been implicated to play a …