A break in mitochondrial endosymbiosis as a basis for inflammatory diseases
MP Murphy, LAJ O'Neill - Nature, 2024 - nature.com
Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …
recognize them as foreign because the organelles are sequestered. However, the regulated …
Mitochondrial dynamics at different levels: from cristae dynamics to interorganellar cross talk
AK Kondadi, AS Reichert - Annual Review of Biophysics, 2024 - annualreviews.org
Mitochondria are essential organelles performing important cellular functions ranging from
bioenergetics and metabolism to apoptotic signaling and immune responses. They are …
bioenergetics and metabolism to apoptotic signaling and immune responses. They are …
A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease
Y Cao, J Zheng, H Wan, Y Sun, S Fu, S Liu, B He… - The EMBO …, 2023 - embopress.org
Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory
mechanisms and pathological implications remain poorly understood. Here, via a …
mechanisms and pathological implications remain poorly understood. Here, via a …
Mitochondrial pores at the crossroad between cell death and inflammatory signaling
Mitochondria are cellular organelles with a major role in many cellular processes, including
not only energy production, metabolism, and calcium homeostasis but also regulated cell …
not only energy production, metabolism, and calcium homeostasis but also regulated cell …
A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass
Y Sun, Y Cao, H Wan, A Memetimin, Y Cao, L Li, C Wu… - Molecular Cell, 2024 - cell.com
Mitophagy mediated by BNIP3 and NIX critically regulates mitochondrial mass. Cellular
BNIP3 and NIX levels are tightly controlled by SCF FBXL4-mediated ubiquitination to …
BNIP3 and NIX levels are tightly controlled by SCF FBXL4-mediated ubiquitination to …
Mitochondrial DNA in cell death and inflammation
R Heilig, J Lee, SWG Tait - Biochemical Society Transactions, 2023 - portlandpress.com
Cytosolic DNA is recognized by the innate immune system as a potential threat. During
apoptotic cell death, mitochondrial DNA (mtDNA) release activates the DNA sensor cyclic …
apoptotic cell death, mitochondrial DNA (mtDNA) release activates the DNA sensor cyclic …
Inflammation, mitochondria and natural compounds together in the circle of trust
S Nesci, A Spagnoletta, F Oppedisano - International Journal of …, 2023 - mdpi.com
Human diseases are characterized by the perpetuation of an inflammatory condition in
which the levels of Reactive Oxygen Species (ROS) are quite high. Excessive ROS …
which the levels of Reactive Oxygen Species (ROS) are quite high. Excessive ROS …
Multifaceted roles of mitochondria in wound healing and chronic wound pathogenesis
Mitochondria are intracellular organelles that play a critical role in numerous cellular
processes including the regulation of metabolism, cellular stress response, and cell fate …
processes including the regulation of metabolism, cellular stress response, and cell fate …
Ozone exposure affects corneal epithelial fate by promoting mtDNA leakage and cGAS/STING activation
K Fan, N Dong, M Fang, Z Xiang, L Zheng… - Journal of Hazardous …, 2024 - Elsevier
Ozone is a common air pollutant associated with various human diseases. The human
ocular surface is frequently exposed to ozone in the troposphere, but the mechanisms by …
ocular surface is frequently exposed to ozone in the troposphere, but the mechanisms by …
Exploring the role of mitochondrial hydrogen sulfide in maintaining polarity and mtDNA integrity with a multichannel fluorescent probe
S Mu, T Han, X Zhang, J Liu, H Sun, J Zhang… - Analytical …, 2023 - ACS Publications
Abnormal mitochondrial state has been implicated in the pathogenesis of various diseases
including neurodegenerative disorders, myopathies, cardiovascular diseases, and cancers …
including neurodegenerative disorders, myopathies, cardiovascular diseases, and cancers …