Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …

Mitochondria are essential organelles performing important cellular functions ranging from
bioenergetics and metabolism to apoptotic signaling and immune responses. They are …

Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory
mechanisms and pathological implications remain poorly understood. Here, via a …

Mitochondria are cellular organelles with a major role in many cellular processes, including
not only energy production, metabolism, and calcium homeostasis but also regulated cell …

Mitophagy mediated by BNIP3 and NIX critically regulates mitochondrial mass. Cellular
BNIP3 and NIX levels are tightly controlled by SCF FBXL4-mediated ubiquitination to …

Cytosolic DNA is recognized by the innate immune system as a potential threat. During
apoptotic cell death, mitochondrial DNA (mtDNA) release activates the DNA sensor cyclic …

Human diseases are characterized by the perpetuation of an inflammatory condition in
which the levels of Reactive Oxygen Species (ROS) are quite high. Excessive ROS …

Mitochondria are intracellular organelles that play a critical role in numerous cellular
processes including the regulation of metabolism, cellular stress response, and cell fate …

Ozone is a common air pollutant associated with various human diseases. The human
ocular surface is frequently exposed to ozone in the troposphere, but the mechanisms by …

Abnormal mitochondrial state has been implicated in the pathogenesis of various diseases
including neurodegenerative disorders, myopathies, cardiovascular diseases, and cancers …