Microfluidic organs-on-chips
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …
methods that contains continuously perfused chambers inhabited by living cells arranged to …
Engineered nanoparticles for drug delivery in cancer therapy
In medicine, nanotechnology has sparked a rapidly growing interest as it promises to solve a
number of issues associated with conventional therapeutic agents, including their poor …
number of issues associated with conventional therapeutic agents, including their poor …
25th anniversary article: Rational design and applications of hydrogels in regenerative medicine
Hydrogels are hydrophilic polymer‐based materials with high water content and physical
characteristics that resemble the native extracellular matrix. Because of their remarkable …
characteristics that resemble the native extracellular matrix. Because of their remarkable …
Lung-on-a-chip: the future of respiratory disease models and pharmacological studies
J Shrestha, S Razavi Bazaz… - Critical reviews in …, 2020 - Taylor & Francis
Abstract Recently, organ-on-a-chip models, which are microfluidic devices that mimic the
cellular architecture and physiological environment of an organ, have been developed and …
cellular architecture and physiological environment of an organ, have been developed and …
Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010
S Adler, D Basketter, S Creton, O Pelkonen… - Archives of …, 2011 - Springer
The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics
on the market in Europe after 2013. In that context, the European Commission invited …
on the market in Europe after 2013. In that context, the European Commission invited …
Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury
The use of nanoparticles in medical applications is highly anticipated, and at the same time
little is known about how these nanoparticles affect human tissues. Here we have simulated …
little is known about how these nanoparticles affect human tissues. Here we have simulated …
The role of body-on-a-chip devices in drug and toxicity studies
MB Esch, TL King, ML Shuler - Annual review of biomedical …, 2011 - annualreviews.org
High-quality, in vitro screening tools are essential in identifying promising compounds
during drug development. Tests with currently used cell-based assays provide an indication …
during drug development. Tests with currently used cell-based assays provide an indication …
Advances in silica based nanoparticles for targeted cancer therapy
Targeted delivery of anticancer drug specifically to tumor site without damaging normal
tissues has been the dream of all scientists fighting against cancer for decades. Recent …
tissues has been the dream of all scientists fighting against cancer for decades. Recent …
Microfabricated mammalian organ systems and their integration into models of whole animals and humans
While in vitro cell based systems have been an invaluable tool in biology, they often suffer
from a lack of physiological relevance. The discrepancy between the in vitro and in vivo …
from a lack of physiological relevance. The discrepancy between the in vitro and in vivo …
ADMET profiling in drug discovery and development: perspectives of in silico, in vitro and integrated approaches
In the drug discovery setting, undesirable ADMET properties of a pharmacophore with good
predictive power obtained after a tedious drug discovery and development process may …
predictive power obtained after a tedious drug discovery and development process may …