Both animal models and human observational and genetic studies have shown that immune
and inflammatory mechanisms play a key role in hypertension and its complications. We …

Hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases,
and its development involves multiple mechanisms. Gut microbiota has been reported to be …

The vagus nerve is involved in the autonomic regulation of physiological homeostasis,
through vast innervation of cervical, thoracic and abdominal visceral organs. Stimulation of …

Bioelectronic medicine (BM) is an emerging new approach for developing novel
neuromodulation therapies for pathologies that have been previously treated with …

Autonomic dysfunction and chronic inflammation contribute to the pathogenesis and
progression of several cardiovascular diseases (CVD), such as heart failure with preserved …

Vagus nerve stimulation (VNS) suppresses inflammation and autoimmune diseases in
preclinical and clinical studies. The underlying molecular, neurological, and anatomical …

Background It has been suggested that vagus nerve stimulation (VNS) may enhance
attention and working memory. The neuromodulator effects of VNS are thought to activate …

Stroke is a devastating cerebrovascular pathology with high morbidity and mortality.
Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation …

Chronic or repeated social stress exposure often precipitates the onset of depression and
cardiovascular disease (CVD). Despite a clear clinical association between CVD and …

Metabolic syndrome (MetS) induces a systemic inflammatory state which can lead to
cardiomyopathy, manifesting clinically as heart failure (HF) with preserved ejection fraction …