Enhanced multiplexing technology for proteomics

BL Bowser, RAS Robinson - Annual Review of Analytical …, 2023 - annualreviews.org
The identification of thousands of proteins and their relative levels of expression has
furthered understanding of biological processes and disease and stimulated new systems …

Posttranslational modifications in systems biology

S Aggarwal, P Tolani, S Gupta, AK Yadav - Advances in Protein Chemistry …, 2021 - Elsevier
The biological complexity cannot be captured by genes or proteins alone. The protein
posttranslational modifications (PTMs) impart functional diversity to the proteome and …

A critical comparison of three MS‐based approaches for quantitative proteomics analysis

D Taverna, M Gaspari - Journal of Mass Spectrometry, 2021 - Wiley Online Library
MS‐based proteomics is expanding its role as a routine tool for biological discovery.
Nevertheless, the task of accurately and precisely quantifying thousands of analytes in a …

Comprehensive overview of bottom-up proteomics using mass spectrometry

Y Jiang, DAB Rex, D Schuster, BA Neely… - ACS Measurement …, 2024 - ACS Publications
Proteomics is the large scale study of protein structure and function from biological systems
through protein identification and quantification.“Shotgun proteomics” or “bottom-up …

Cerebrospinal fluid proteomic signatures are associated with symptom severity of first-episode psychosis

H Haroon, AMC Ho, VK Gupta, S Dasari… - Journal of Psychiatric …, 2024 - Elsevier
Apart from their diagnostic, monitoring, or prognostic utility in clinical settings, molecular
biomarkers may be instrumental in understanding the pathophysiology of psychiatric …

Studying autophagy using a TMT-based quantitative proteomics approach

KB Sharma, S Aggarwal, AK Yadav, S Vrati… - Autophagy and Cancer …, 2022 - Springer
Maintenance of cellular homeostasis through regulated degradation of proteins and
organelles is a defining feature of autophagy. This process itself is tightly regulated in a …

DynaTMT: A user-friendly tool to process combined SILAC/TMT data

K Klann, D Krause, C Münch - bioRxiv, 2021 - biorxiv.org
The measurement of protein dynamics by proteomics to study cell remodeling has seen
increased attention over the last years. This development is largely driven by a number of …