Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases

A Buonacera, B Stancanelli, M Colaci… - International journal of …, 2022 - mdpi.com
Over the last 10 years, the evaluation of the neutrophil-to-lymphocyte ratio (NLR) as an
emerging marker of diseases has become a compelling field of bio-medical research …

Neutrophils as emerging therapeutic targets

T Németh, M Sperandio, A Mócsai - Nature reviews Drug discovery, 2020 - nature.com
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

J Schulte-Schrepping, N Reusch, D Paclik, K Baßler… - Cell, 2020 - cell.com
Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …

Neutrophil diversity in health and disease

C Silvestre-Roig, ZG Fridlender, M Glogauer… - Trends in …, 2019 - cell.com
New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

Cell membrane-coated mimics: a methodological approach for fabrication, characterization for therapeutic applications, and challenges for clinical translation

V Chugh, K Vijaya Krishna, A Pandit - ACS nano, 2021 - ACS Publications
Cell membrane-coated (CMC) mimics are micro/nanosystems that combine an isolated cell
membrane and a template of choice to mimic the functions of a cell. The design exploits its …

The neutrophil life cycle

A Hidalgo, ER Chilvers, C Summers… - Trends in …, 2019 - cell.com
Neutrophils are recognized as an essential part of the innate immune response, but an
active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in …

Neutrophil extracellular traps and their implications in cardiovascular and inflammatory disease

J Klopf, C Brostjan, W Eilenberg… - International journal of …, 2021 - mdpi.com
Neutrophils are primary effector cells of innate immunity and fight infection by phagocytosis
and degranulation. Activated neutrophils also release neutrophil extracellular traps (NETs) …

The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens

A Ulfig, LI Leichert - Cellular and Molecular Life Sciences, 2021 - Springer
Neutrophils are predominant immune cells that protect the human body against infections by
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …

The role of reactive species on innate immunity

CMC Andrés, JM Pérez de la Lastra, CA Juan, FJ Plou… - Vaccines, 2022 - mdpi.com
This review examines the role of reactive species RS (of oxygen ROS, nitrogen RNS and
halogen RHS) on innate immunity. The importance of these species in innate immunity was …

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19

G Carissimo, W Xu, I Kwok, MY Abdad, YH Chan… - Nature …, 2020 - nature.com
SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic.
Severe complications are observed only in a small proportion of infected patients but the …