DNA methylation-based biomarkers and the epigenetic clock theory of ageing
S Horvath, K Raj - Nature reviews genetics, 2018 - nature.com
Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
A systematic review and meta-analysis of environmental, lifestyle, and health factors associated with DNA methylation age
J Ryan, J Wrigglesworth, J Loong… - The Journals of …, 2020 - academic.oup.com
DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an
individual's chronological age and can predict their risk of age-related disease and mortality …
individual's chronological age and can predict their risk of age-related disease and mortality …
[HTML][HTML] Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients
It has been a long standing hypothesis that blood tissue of PD Parkinson's disease (PD)
patients may exhibit signs of accelerated aging. Here we use DNA methylation based …
patients may exhibit signs of accelerated aging. Here we use DNA methylation based …
[HTML][HTML] Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling
Background Chronic psychological stress is associated with accelerated aging and
increased risk for aging-related diseases, but the underlying molecular mechanisms are …
increased risk for aging-related diseases, but the underlying molecular mechanisms are …
[HTML][HTML] Evidence for biological age acceleration and telomere shortening in COVID-19 survivors
A Mongelli, V Barbi, M Gottardi Zamperla… - International journal of …, 2021 - mdpi.com
The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst
cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine …
cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine …
[HTML][HTML] How to slow down the ticking clock: age-associated epigenetic alterations and related interventions to extend life span
Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …
overview on recent findings describing the epigenetic changes that arise during aging and …
[HTML][HTML] Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals
Background Human aging is associated with profound changes in one of the major
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …
[HTML][HTML] Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression
Background Epigenetic clocks use DNA methylation (DNAm) levels of specific sets of CpG
dinucleotides to accurately predict individual chronological age. A popular application of …
dinucleotides to accurately predict individual chronological age. A popular application of …
[HTML][HTML] Human cytomegalovirus and autoimmune diseases: where are we?
F Gugliesi, S Pasquero, G Griffante, S Scutera… - Viruses, 2021 - mdpi.com
Human cytomegalovirus (HCMV) is a ubiquitous double-stranded DNA virus belonging to
the β-subgroup of the herpesvirus family. After the initial infection, the virus establishes …
the β-subgroup of the herpesvirus family. After the initial infection, the virus establishes …
[HTML][HTML] Vaccination as a preventative measure contributing to immune fitness
B Laupèze, G Del Giudice, MT Doherty, R Van der Most - npj Vaccines, 2021 - nature.com
The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect
consequences may include maintenance of homeostasis through prevention of infection …
consequences may include maintenance of homeostasis through prevention of infection …